Intracellular lipid binding protein
IPR031259
Definition
Fatty acid binding proteins (FABPs) and cellular retinoic-acid-binding proteins (CRBPs) are part of the intracellular-lipid-binding proteins (iLBPs) family PMID:12479570. The primary role of all the FABP members is regulation of fatty acid uptake and intracellular transport PMID:16424607. To date, nine FABPs have been identified in mammals, each showing specific tissue distribution patterns and ligand preference. All FABP members have a similar β-barrel structure; fatty acid ligands are accommodated in the central cavity of the β-barrel, which dramatically increases their solubility in the aqueous cytoplasm, facilitating their movement to target sites [[cite:PMID:16424607], [cite:PMID:9082452]]. Retinoic-acid-binding proteins (CRBPs) are specific for vitamin A derivatives and can be classified into the cellular retinoic acid-binding proteins (CRABP-I and II) and the cellular retinol-binding proteins (CRBP-I, II, III, and IV) PMID:15234551.
17 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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