Seroatlas · Human Serome Atlas

CRABP2

Cellular retinoic acid-binding protein 2

Also known as: CRABP-II, RABP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P29373
Gene: CRABP2
Ensembl: ENSG00000143320
Chromosome: 1
Canonical length: 138 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>P29373|CRABP2
     1  MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT FYIKTSTTVR
    61  TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL LKGEGPKTSW TRELTNDGEL
   121  ILTMTADDVV CTRVYVRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRABP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 1,174 nTPM

Expression across tissuesHPA

Tissue

esophagus: 1,174 nTPM
vagina: 590 nTPM
cervix: 567 nTPM
skin: 174 nTPM
choroid plexus: 152 nTPM
breast: 98 nTPM

Single-cell type

esophageal suprabasal cells: 4,577 nCPM
esophageal basal cells: 1,651 nCPM
esophageal apical cells: 1,358 nCPM
breast secretory cells: 611 nCPM
prostatic club cells: 420 nCPM
epididymal basal cells: 338 nCPM

Immune cell

memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 55 nTPM
cerebral cortex: 34 nTPM
hypothalamus: 18 nTPM
basal ganglia: 15 nTPM
hippocampal formation: 14 nTPM
cerebellum: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRABP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRABP2 as an antibody target. Whether an autoantibody or antibody against CRABP2 could matter depends on whether native CRABP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRABP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CRABP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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