Seroatlas · Human Serome Atlas

RBP7

Retinoid-binding protein 7

Also known as: CRBPIV, RET7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96R05
Gene: RBP7
Ensembl: ENSG00000162444
Chromosome: 1
Canonical length: 134 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the cellular retinol-binding protein (CRBP) family, whose members are required for vitamin A stability and metabolism. The encoded protein binds all-trans-retinol and is structurally similar to other CRBPs; however, it has a lower binding affinity for retinol than other CRBPs. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q96R05|RBP7
     1  MPADLSGTWT LLSSDNFEGY MLALGIDFAT RKIAKLLKPQ KVIEQNGDSF TIHTNSSLRN
    61  YFVKFKVGEE FDEDNRGLDN RKCKSLVIWD NDRLTCIQKG EKKNRGWTHW IEGDKLHLEM
   121  FCEGQVCKQT FQRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 412 nTPM

Expression across tissuesHPA

Tissue

breast: 412 nTPM
adipose tissue: 390 nTPM
spleen: 110 nTPM
heart muscle: 88 nTPM
kidney: 76 nTPM
parathyroid gland: 65 nTPM

Single-cell type

kupffer cells: 987 nCPM
esophageal apical cells: 587 nCPM
vascular endothelial cells: 377 nCPM
monocytes: 151 nCPM
neutrophils: 117 nCPM
hofbauer cells: 94 nCPM

Immune cell

neutrophil: 347 nTPM
classical monocyte: 313 nTPM
intermediate monocyte: 139 nTPM
total PBMC: 97 nTPM
non-classical monocyte: 69 nTPM
myeloid DC: 11 nTPM

Brain region

white matter: 41 nTPM
basal ganglia: 21 nTPM
medulla oblongata: 15 nTPM
cerebellum: 15 nTPM
midbrain: 15 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0.54
gnomAD missense Z: 1.08
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

fatty acid transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBP7 as an antibody target. Whether an autoantibody or antibody against RBP7 could matter depends on whether native RBP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...