Seroatlas · Human Serome Atlas

FABP7

Fatty acid-binding protein, brain

Also known as: B-FABP, BLBP, FABP7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15540
Gene: FABP7
Ensembl: ENSG00000164434
Chromosome: 6
Canonical length: 132 aa
Protein class: FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>O15540|FABP7
     1  MVEAFCATWK LTNSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGDKV VIRTLSTFKN
    61  TEISFQLGEE FDETTADDRN CKSVVSLDGD KLVHIQKWDG KETNFVREIK DGKMVMTLTF
   121  GDVVAVRHYE KA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FABP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 232 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 232 nTPM
cerebral cortex: 194 nTPM
tongue: 186 nTPM
amygdala: 175 nTPM
retina: 162 nTPM
hippocampal formation: 135 nTPM

Single-cell type

müller glia: 896 nCPM
extravillous trophoblasts: 326 nCPM
breast secretory cells: 97 nCPM
migrating cytotrophoblasts: 75 nCPM
bergmann glia: 47 nCPM
oligodendrocyte progenitor cells: 45 nCPM

Immune cell

basophil: 0.6 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 153 nTPM
basal ganglia: 115 nTPM
cerebral cortex: 104 nTPM
hippocampal formation: 70 nTPM
medulla oblongata: 70 nTPM
amygdala: 60 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FABP7.

Disease | ImmuneIEDB

Conditions an epitope on FABP7 was assayed in.

glioblastoma T cell
malignant astrocytoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FABP7 as an antibody target. Whether an autoantibody or antibody against FABP7 could matter depends on whether native FABP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FABP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FABP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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