Seroatlas · Human Serome Atlas

RBP5

Retinol-binding protein 5

Also known as: CRBPIII, RET5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P82980
Gene: RBP5
Ensembl: ENSG00000139194
Chromosome: 12
Canonical length: 135 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a cellular retinol-binding protein expressed highly in kidney and liver. Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

135 residues, UniProt reviewed canonical sequence.

>P82980|RBP5
     1  MPPNLTGYYR FVSQKNMEDY LQALNISLAV RKIALLLKPD KEIEHQGNHM TVRTLSTFRN
    61  YTVQFDVGVE FEEDLRSVDG RKCQTIVTWE EEHLVCVQKG EVPNRGWRHW LEGEMLYLEL
   121  TARDAVCEQV FRKVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 453 nTPM

Expression across tissuesHPA

Tissue

kidney: 453 nTPM
liver: 329 nTPM
spleen: 97 nTPM
lymph node: 29 nTPM
small intestine: 20 nTPM
tonsil: 20 nTPM

Single-cell type

hepatocytes: 217 nCPM
epididymal efferent duct absorptive cells: 42 nCPM
proximal tubule cells: 41 nCPM
vascular endothelial cells: 7.3 nCPM
loop of henle epithelial cells: 6.6 nCPM
hepatic stellate cells: 6.5 nCPM

Immune cell

T-reg: 0.3 nTPM
basophil: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 2.3 nTPM
cerebral cortex: 1.9 nTPM
midbrain: 1.9 nTPM
cerebellum: 1.8 nTPM
pons: 1.8 nTPM
thalamus: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

fatty acid transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBP5 as an antibody target. Whether an autoantibody or antibody against RBP5 could matter depends on whether native RBP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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