RBP2
Retinol-binding protein 2
Also known as: CRABP-II, CRBP2, CRBPII, RBPC2, RET2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P50120
- Gene
- RBP2
- Ensembl
- ENSG00000114113
- Chromosome
- 3
- Canonical length
- 134 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins, Transporters
- Subcellular location
- Golgi apparatus
OverviewNCBI Gene
This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015]
Canonical amino-acid sequenceUniProt
134 residues, UniProt reviewed canonical sequence.
>P50120|RBP2
1 MTRDQNGTWE MESNENFEGY MKALDIDFAT RKIAVRLTQT KVIDQDGDNF KTKTTSTFRN
61 YDVDFTVGVE FDEYTKSLDN RHVKALVTWE GDVLVCVQKG EKENRGWKQW IEGDKLYLEL
121 TCGDQVCRQV FKKKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 2,548 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 2,548 nTPM
- small intestine: 1,775 nTPM
- lung: 7.1 nTPM
- stomach: 3.4 nTPM
- colon: 3.3 nTPM
- pancreas: 2.9 nTPM
Single-cell type
- enterocytes: 5,631 nCPM
- enteric transient amplifying cells: 170 nCPM
- paneth cells: 97 nCPM
- epicardial cells: 68 nCPM
- goblet cells: 64 nCPM
- cardiomyocytes: 60 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 40 nTPM
- hypothalamus: 38 nTPM
- medulla oblongata: 38 nTPM
- white matter: 30 nTPM
- amygdala: 30 nTPM
- cerebral cortex: 28 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.88
- gnomAD pLI
- 0.22
- gnomAD missense Z
- 0.38
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- epidermis development
- fatty acid transport
- triglyceride biosynthetic process
- vitamin A metabolic process
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RBP2 as an antibody target. Whether an autoantibody or antibody against RBP2 could matter depends on whether native RBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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