Seroatlas · Human Serome Atlas

FABP9

Fatty acid-binding protein 9

Also known as: FABP9_HUMAN, PERF, PERF15, T-FABP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q0Z7S8
Gene
FABP9
Ensembl
ENSG00000205186
Chromosome
8
Canonical length
132 aa
Protein class
Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable long-chain fatty acid binding activity. Predicted to be involved in long-chain fatty acid transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q0Z7S8|FABP9
     1  MVEPFLGTWK LVSSENFEDY MKELGVNFAA RNMAGLVKPT VTISVDGKMM TIRTESSFQD
    61  TKISFKLGEE FDETTADNRK VKSTITLENG SMIHVQKWLG KETTIKRKIV DEKMVVECKM
   121  NNIVSTRIYE KV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FABP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • skin: 34 nTPM
  • adipose tissue: 1 nTPM
  • retina: 0.9 nTPM
  • breast: 0.8 nTPM
  • salivary gland: 0.5 nTPM
  • testis: 0.2 nTPM

Single-cell type

  • retinal ganglion cells: 3.9 nCPM
  • ocular epithelial cells: 2 nCPM
  • adipocytes: 1.8 nCPM
  • epididymal efferent duct ciliated cells: 0.8 nCPM
  • pericytes: 0.8 nCPM
  • rod photoreceptor cells: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.2 nTPM
  • medulla oblongata: 0.9 nTPM
  • spinal cord: 0.7 nTPM
  • cerebral cortex: 0.6 nTPM
  • basal ganglia: 0.3 nTPM
  • cerebellum: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.96
gnomAD pLI
0
gnomAD missense Z
0.01

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FABP9 as an antibody target. Whether an autoantibody or antibody against FABP9 could matter depends on whether native FABP9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FABP9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FABP9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FABP9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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