FABP6
Gastrotropin
Also known as: FABP6_HUMAN, I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P51161
- Gene
- FABP6
- Ensembl
- ENSG00000170231
- Chromosome
- 5
- Canonical length
- 128 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
128 residues, UniProt reviewed canonical sequence.
>P51161|FABP6
1 MAFTGKFEME SEKNYDEFMK LLGISSDVIE KARNFKIVTE VQQDGQDFTW SQHYSGGHTM
61 TNKFTVGKES NIQTMGGKTF KATVQMEGGK LVVNFPNYHQ TSEIVGDKLV EVSTIGGVTY
121 ERVSKRLALocalizationUniProt · AlphaFold · HPA
Whether an antibody against FABP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 4,265 nTPM
Expression across tissuesHPA
Tissue
- small intestine: 4,265 nTPM
- fallopian tube: 51 nTPM
- hypothalamus: 18 nTPM
- midbrain: 14 nTPM
- adrenal gland: 14 nTPM
- basal ganglia: 13 nTPM
Single-cell type
- enterocytes: 49,087 nCPM
- enteric transient amplifying cells: 2,337 nCPM
- respiratory ciliated cells: 558 nCPM
- goblet cells: 522 nCPM
- paneth cells: 398 nCPM
- fallopian tube ciliated cells: 342 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 12 nTPM
- medulla oblongata: 11 nTPM
- spinal cord: 8.4 nTPM
- thalamus: 8.3 nTPM
- pons: 7.7 nTPM
- choroid plexus: 7.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.65
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.5
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FABP6 as an antibody target. Whether an autoantibody or antibody against FABP6 could matter depends on whether native FABP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FABP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FABP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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