CRABP1
Cellular retinoic acid-binding protein 1
Also known as: CRABP, CRABP-I, CRABPI, RABP1_HUMAN, RBP5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P29762
- Gene
- CRABP1
- Ensembl
- ENSG00000166426
- Chromosome
- 15
- Canonical length
- 137 aa
- Protein class
- Cancer-related genes, Plasma proteins, Predicted intracellular proteins
OverviewNCBI Gene
This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
137 residues, UniProt reviewed canonical sequence.
>P29762|CRABP1
1 MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR
61 TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI
121 LTFGADDVVC TRIYVRELocalizationUniProt · AlphaFold · HPA
Whether an antibody against CRABP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 505 nTPM
Expression across tissuesHPA
Tissue
- retina: 505 nTPM
- thyroid gland: 163 nTPM
- choroid plexus: 94 nTPM
- basal ganglia: 84 nTPM
- hypothalamus: 82 nTPM
- spleen: 75 nTPM
Single-cell type
- müller glia: 3,412 nCPM
- oocytes: 355 nCPM
- melanocytes: 241 nCPM
- breast lactating cells: 197 nCPM
- breast secretory cells: 86 nCPM
- retinal amacrine cells: 57 nCPM
Immune cell
- myeloid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- thalamus: 182 nTPM
- medulla oblongata: 117 nTPM
- midbrain: 117 nTPM
- pons: 112 nTPM
- hypothalamus: 70 nTPM
- choroid plexus: 49 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.44
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.8
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CRABP1 as an antibody target. Whether an autoantibody or antibody against CRABP1 could matter depends on whether native CRABP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CRABP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CRABP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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