Seroatlas · Human Serome Atlas

FABP2

Fatty acid-binding protein, intestinal

Also known as: FABPI_HUMAN, I-FABP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P12104
Gene: FABP2
Ensembl: ENSG00000145384
Chromosome: 4
Canonical length: 132 aa
Protein class: Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and proliferation. This protein binds saturated long-chain fatty acids with high affinity, and may act as a lipid sensor to maintain energy homeostasis. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>P12104|FABP2
     1  MAFDSTWKVD RSENYDKFME KMGVNIVKRK LAAHDNLKLT ITQEGNKFTV KESSTFRNIE
    61  VVFELGVTFN YNLADGTELR GTWSLEGNKL IGKFKRTDNG NELNTVREII GDELVQTYVY
   121  EGVEAKRIFK KD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FABP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 518 nTPM

Expression across tissuesHPA

Tissue

small intestine: 518 nTPM
duodenum: 274 nTPM
rectum: 33 nTPM
colon: 27 nTPM
appendix: 3 nTPM
choroid plexus: 2.3 nTPM

Single-cell type

enterocytes: 5,634 nCPM
goblet cells: 448 nCPM
enteric transient amplifying cells: 240 nCPM
colonocytes: 205 nCPM
paneth cells: 190 nCPM
enteric stem cells: 65 nCPM

Immune cell

neutrophil: 4.2 nTPM
basophil: 1.6 nTPM
classical monocyte: 0.4 nTPM
eosinophil: 0.4 nTPM
NK-cell: 0.4 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

cerebellum: 5.4 nTPM
choroid plexus: 5.2 nTPM
cerebral cortex: 4.7 nTPM
hippocampal formation: 4.6 nTPM
white matter: 4.6 nTPM
hypothalamus: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cytosolic fatty-acid binding
Lipocalin/cytosolic fatty-acid binding domain
Calycin
Intracellular lipid binding protein
Lipocalin / cytosolic fatty-acid binding protein family
Fatty acid-binding protein, intestinal

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FABP2 as an antibody target. Whether an autoantibody or antibody against FABP2 could matter depends on whether native FABP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FABP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FABP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...