FABP3

Protein identityUniProt · HPA

UniProt accession

P05413

Gene

FABP3

Ensembl

ENSG00000121769

Chromosome

1

Canonical length

133 aa

Protein class

Candidate cardiovascular disease genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Golgi apparatus,Plasma membrane,Focal adhesion sites

OverviewNCBI Gene

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

133 residues, UniProt reviewed canonical sequence.

>P05413|FABP3
     1  MVDAFLGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDIL TLKTHSTFKN
    61  TEISFKLGVE FDETTADDRK VKSIVTLDGG KLVHLQKWDG QETTLVRELI DGKLILTLTH
   121  GTAVCTRTYE KEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FABP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

1,398 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.87

gnomAD pLI

0.44

gnomAD missense Z

0.42

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• brown fat cell differentiation
• cholesterol homeostasis
• fatty acid metabolic process
• intracellular lipid transport
• long-chain fatty acid transport
• negative regulation of cell population proliferation
• phospholipid homeostasis
• positive regulation of phospholipid biosynthetic process
• regulation of fatty acid oxidation
• response to fatty acid
• response to insulin
• response to xenobiotic stimulus
• positive regulation of long-chain fatty acid import into cell
• regulation of phosphatidylcholine biosynthetic process

Molecular functions

• cytoskeletal protein binding
• long-chain fatty acid binding
• long-chain fatty acid transmembrane transporter activity
• oleic acid binding
• icosatetraenoic acid binding

Cellular components

• cytosol
• extracellular exosome
• extracellular space
• nucleus
• sarcoplasm

Protein domainsUniProt · Pfam · InterPro

• Cytosolic fatty-acid binding
• Lipocalin/cytosolic fatty-acid binding domain
• Calycin
• Intracellular lipid binding protein
• Lipocalin / cytosolic fatty-acid binding protein family

KeywordsUniProt

• Acetylation
• Cytoplasm
• Lipid-binding
• Phosphoprotein
• Transport

InteractionsUniProt · HPA

Protein binding partners of FABP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TNNI3K