Seroatlas · Human Serome Atlas

FABP12

Fatty acid-binding protein 12

Also known as: FBP12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFH5
Gene: FABP12
Ensembl: ENSG00000197416
Chromosome: 8
Canonical length: 140 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable fatty acid binding activity. Predicted to be involved in fatty acid transport. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>A6NFH5|FABP12
     1  MIDQLQGTWK SISCENSEDY MKELGIGRAS RKLGRLAKPT VTISTDGDVI TIKTKSIFKN
    61  NEISFKLGEE FEEITPGGHK TKSKVTLDKE SLIQVQDWDG KETTITRKLV DGKMVVESTV
   121  NSVICTRTYE KVSSNSVSNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FABP12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

retina: 52 nTPM
testis: 6.9 nTPM
esophagus: 2.2 nTPM
duodenum: 0.4 nTPM
lung: 0.3 nTPM
cervix: 0.1 nTPM

Single-cell type

rod photoreceptor cells: 315 nCPM
late spermatids: 207 nCPM
cone photoreceptor cells: 164 nCPM
early spermatids: 119 nCPM
esophageal suprabasal cells: 58 nCPM
esophageal basal cells: 48 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.8 nTPM
basal ganglia: 0.4 nTPM
medulla oblongata: 0.4 nTPM
white matter: 0.4 nTPM
cerebral cortex: 0.3 nTPM
spinal cord: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

fatty acid transport

Molecular functions

fatty acid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FABP12 as an antibody target. Whether an autoantibody or antibody against FABP12 could matter depends on whether native FABP12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FABP12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FABP12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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