Seroatlas · Human Serome Atlas

FABP1

Fatty acid-binding protein, liver

Also known as: FABPL_HUMAN, L-FABP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P07148
Gene: FABP1
Ensembl: ENSG00000163586
Chromosome: 2
Canonical length: 127 aa
Protein class: Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>P07148|FABP1
     1  MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ
    61  NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF
   121  KRISKRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FABP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 12,176 nTPM

Expression across tissuesHPA

Tissue

liver: 12,176 nTPM
colon: 5,140 nTPM
duodenum: 4,461 nTPM
small intestine: 4,445 nTPM
rectum: 3,200 nTPM
kidney: 749 nTPM

Single-cell type

colonocytes: 24,611 nCPM
enterocytes: 14,089 nCPM
hepatocytes: 5,908 nCPM
enteric transient amplifying cells: 5,232 nCPM
enteric stem cells: 855 nCPM
goblet cells: 742 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 0.7 nTPM
amygdala: 0.6 nTPM
cerebral cortex: 0.5 nTPM
hypothalamus: 0.5 nTPM
thalamus: 0.5 nTPM
basal ganglia: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FABP1 as an antibody target. Whether an autoantibody or antibody against FABP1 could matter depends on whether native FABP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FABP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FABP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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