Seroatlas · Human Serome Atlas

FABP5

Fatty acid-binding protein 5

Also known as: E-FABP, FABP5_HUMAN, KFABP, PA-FABP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q01469
Gene: FABP5
Ensembl: ENSG00000164687
Chromosome: 8
Canonical length: 135 aa
Protein class: Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Plasma membrane,Cytosol
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

135 residues, UniProt reviewed canonical sequence.

>Q01469|FABP5
     1  MATVQQLEGR WRLVDSKGFD EYMKELGVGI ALRKMGAMAK PDCIITCDGK NLTIKTESTL
    61  KTTQFSCTLG EKFEETTADG RKTQTVCNFT DGALVQHQEW DGKESTITRK LKDGKLVVEC
   121  VMNNVTCTRI YEKVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FABP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 4,866 nTPM

Expression across tissuesHPA

Tissue

esophagus: 4,866 nTPM
vagina: 3,491 nTPM
cervix: 2,768 nTPM
choroid plexus: 1,754 nTPM
skin: 921 nTPM
salivary gland: 628 nTPM

Single-cell type

esophageal suprabasal cells: 12,603 nCPM
esophageal basal cells: 7,538 nCPM
ocular epithelial cells: 4,933 nCPM
esophageal apical cells: 4,150 nCPM
suprabasal keratinocytes: 3,004 nCPM
urothelial cells: 1,528 nCPM

Immune cell

myeloid DC: 56 nTPM
plasmacytoid DC: 55 nTPM
NK-cell: 22 nTPM
memory B-cell: 17 nTPM
intermediate monocyte: 17 nTPM
classical monocyte: 14 nTPM

Brain region

choroid plexus: 480 nTPM
medulla oblongata: 175 nTPM
pons: 126 nTPM
white matter: 120 nTPM
spinal cord: 112 nTPM
hypothalamus: 108 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0.05
gnomAD missense Z: -0.14

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FABP5 as an antibody target. Whether an autoantibody or antibody against FABP5 could matter depends on whether native FABP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FABP5 is annotated as secreted, so native FABP5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FABP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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