Seroatlas · Human Serome Atlas

FABP4

Fatty acid-binding protein, adipocyte

Also known as: A-FABP, aP2, FABP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P15090
Gene: FABP4
Ensembl: ENSG00000170323
Chromosome: 8
Canonical length: 132 aa
Protein class: Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>P15090|FABP4
     1  MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN
    61  TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM
   121  KGVTSTRVYE RA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FABP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 3,556 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 3,556 nTPM
breast: 2,417 nTPM
choroid plexus: 357 nTPM
blood vessel: 287 nTPM
urinary bladder: 226 nTPM
placenta: 175 nTPM

Single-cell type

urothelial cells: 1,744 nCPM
vascular endothelial cells: 1,669 nCPM
adipocytes: 1,143 nCPM
pericytes: 1,117 nCPM
lymphatic endothelial cells: 944 nCPM
vascular smooth muscle cells: 342 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 72 nTPM
thalamus: 7.2 nTPM
hippocampal formation: 1.1 nTPM
basal ganglia: 0.9 nTPM
cerebral cortex: 0.8 nTPM
cerebellum: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FABP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FABP4 as an antibody target. Whether an autoantibody or antibody against FABP4 could matter depends on whether native FABP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FABP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FABP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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