SANT domain
IPR017884
Definition
The SANT domain is a motif of ~50 amino acids present in proteins involved in chromatin-remodelling and transcription regulation. This eukaryotic domain was identified in nuclear receptor co-repressors and named after switching-defective protein 3 (Swi3), adaptor 2 (Ada2), nuclear receptor co-repressor (N-CoR) and transcription factor (TF)IIIB PMID:8882580. Although SANT domains show remarkable sequence and structural similarity to the DNA-binding helix-turn-helix (HTH) domain of the myb-like tandem repeat, their function is not DNA binding. Instead, SANT domains are protein-protein interaction modules and some can bind to histone tails (e.g. in Ada2 and SMRT). The SANT domain has been proposed to function as a histone-interaction module that couples histone-tail binding to enzyme catalysis for the remodelling of nucleosomes [[cite:PMID:14536084], [cite:PMID:15040448]]. SANT domains are found in combination with other domains, such as the SWIRM domain ([interpro:IPR007526]), the ZZ-type zinc finger (see [interpro:IPR000433]), the C2H2-type zinc finger, the GATA-type zinc finger ([interpro:IPR000679]), the MPN-domain and DEAH ATP-helicase domain.
27 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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