Alkaline-phosphatase-like, core domain superfamily
IPR017850
Definition
This superfamily represents a structural domain with a core 3-layer α/β/α structure, which can sometimes contain additional subdomains (also covered by this entry). These domains form the core domain of alkaline phosphatases. This structural domain is found in: Alkaline phosphatase ([ec:3.1.3.1]); most use zinc and magnesium as cofactors [[cite:PMID:15938627], [cite:PMID:15946677]]. Arylsulphatase (has an additional C-terminal α+β subdomain) ([ec:3.1.6.8]) [[cite:PMID:9521684], [cite:PMID:12657638]]. Phosphoglycerate mutase (catalytic domain) ([ec:5.4.2.1]) PMID:12729763. Phosphonoacetate hydrolase (contains an α+β subdomain inserted near C terminus) ([ec:3.11.1.2]); uses zinc as a cofactor. Phosphoenolmutase ([ec:5.4.2.7]).
31 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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