Seroatlas · Human Serome Atlas

ENPP5

Ectonucleotide pyrophosphatase/phosphodiesterase family member 5

Also known as: ENPP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJA9
Gene: ENPP5
Ensembl: ENSG00000112796
Chromosome: 6
Canonical length: 477 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a type-I transmembrane glycoprotein. Studies in rat suggest the encoded protein may play a role in neuronal cell communications. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q9UJA9|ENPP5
     1  MTSKFLLVSF ILAALSLSTT FSLQPDQQKV LLVSFDGFRW DYLYKVPTPH FHYIMKYGVH
    61  VKQVTNVFIT KTYPNHYTLV TGLFAENHGI VANDMFDPIR NKSFSLDHMN IYDSKFWEEA
   121  TPIWITNQRA GHTSGAAMWP GTDVKIHKRF PTHYMPYNES VSFEDRVAKI IEWFTSKEPI
   181  NLGLLYWEDP DDMGHHLGPD SPLMGPVISD IDKKLGYLIQ MLKKAKLWNT LNLIITSDHG
   241  MTQCSEERLI ELDQYLDKDH YTLIDQSPVA AILPKEGKFD EVYEALTHAH PNLTVYKKED
   301  VPERWHYKYN SRIQPIIAVA DEGWHILQNK SDDFLLGNHG YDNALADMHP IFLAHGPAFR
   361  KNFSKEAMNS TDLYPLLCHL LNITAMPHNG SFWNVQDLLN SAMPRVVPYT QSTILLPGSV
   421  KPAEYDQEGS YPYFIGVSLG SIIVIVFFVI FIKHLIHSQI PALQDMHAEI AQPLLQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENPP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 230 nTPM

Expression across tissuesHPA

Tissue

epididymis: 230 nTPM
thyroid gland: 48 nTPM
parathyroid gland: 44 nTPM
testis: 33 nTPM
seminal vesicle: 29 nTPM
retina: 28 nTPM

Single-cell type

epididymal principal cells: 395 nCPM
pituicytes/fscs: 206 nCPM
müller glia: 133 nCPM
sertoli cells: 114 nCPM
myosatellite cells: 82 nCPM
prostatic glandular cells: 78 nCPM

Immune cell

gdT-cell: 15 nTPM
memory CD8 T-cell: 9.7 nTPM
naive CD8 T-cell: 8.7 nTPM
MAIT T-cell: 8 nTPM
total PBMC: 3.2 nTPM
memory CD4 T-cell: 3 nTPM

Brain region

thalamus: 38 nTPM
midbrain: 36 nTPM
cerebral cortex: 35 nTPM
hypothalamus: 29 nTPM
basal ganglia: 24 nTPM
cerebellum: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: 0.04
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell communication

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENPP5 as an antibody target. Whether an autoantibody or antibody against ENPP5 could matter depends on whether native ENPP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENPP5 is annotated as secreted, so native ENPP5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ENPP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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