Seroatlas · Human Serome Atlas

ARSD

Arylsulfatase D

Also known as: ARSD_HUMAN, ASD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51689
Gene
ARSD
Ensembl
ENSG00000006756
Chromosome
X
Canonical length
593 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Lipid droplets

OverviewNCBI Gene

The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>P51689|ARSD
     1  MRSAARRGRA APAARDSLPV LLFLCLLLKT CEPKTANAFK PNILLIMADD LGTGDLGCYG
    61  NNTLRTPNID QLAEEGVRLT QHLAAAPLCT PSRAAFLTGR HSFRSGMDAS NGYRALQWNA
   121  GSGGLPENET TFARILQQHG YATGLIGKWH QGVNCASRGD HCHHPLNHGF DYFYGMPFTL
   181  TNDCDPGRPP EVDAALRAQL WGYTQFLALG ILTLAAGQTC GFFSVSARAV TGMAGVGCLF
   241  FISWYSSFGF VRRWNCILMR NHDVTEQPMV LEKTASLMLK EAVSYIERHK HGPFLLFLSL
   301  LHVHIPLVTT SAFLGKSQHG LYGDNVEEMD WLIGKVLNAI EDNGLKNSTF TYFTSDHGGH
   361  LEARDGHSQL GGWNGIYKGG KGMGGWEGGI RVPGIFHWPG VLPAGRVIGE PTSLMDVFPT
   421  VVQLVGGEVP QDRVIDGHSL VPLLQGAEAR SAHEFLFHYC GQHLHAARWH QKDSGSVWKV
   481  HYTTPQFHPE GAGACYGRGV CPCSGEGVTH HRPPLLFDLS RDPSEARPLT PDSEPLYHAV
   541  IARVGAAVSE HRQTLSPVPQ QFSMSNILWK PWLQPCCGHF PFCSCHEDGD GTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARSD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • liver: 37 nTPM
  • kidney: 36 nTPM
  • pancreas: 31 nTPM
  • stomach: 29 nTPM
  • fallopian tube: 26 nTPM
  • cervix: 23 nTPM

Single-cell type

  • hepatocytes: 149 nCPM
  • fallopian tube ciliated cells: 101 nCPM
  • mucous neck cells: 83 nCPM
  • endometrial glandular cells: 83 nCPM
  • parietal cells: 81 nCPM
  • endometrial ciliated cells: 76 nCPM

Immune cell

  • classical monocyte: 5.8 nTPM
  • intermediate monocyte: 5 nTPM
  • myeloid DC: 4.4 nTPM
  • eosinophil: 4.1 nTPM
  • plasmacytoid DC: 3 nTPM
  • total PBMC: 2.5 nTPM

Brain region

  • choroid plexus: 20 nTPM
  • medulla oblongata: 11 nTPM
  • midbrain: 9.8 nTPM
  • spinal cord: 9.5 nTPM
  • hypothalamus: 8.5 nTPM
  • white matter: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
1.09
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARSD as an antibody target. Whether an autoantibody or antibody against ARSD could matter depends on whether native ARSD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARSD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARSD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARSD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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