ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6
Also known as: ENPP6_HUMAN, MGC33971
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UWR7
- Gene
- ENPP6
- Ensembl
- ENSG00000164303
- Chromosome
- 4
- Canonical length
- 440 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Golgi apparatus
- Secretome location
- Intracellular and membrane
- Quaternary structure
- Homotetramer
OverviewNCBI Gene
Enables glycerophosphocholine cholinephosphodiesterase activity. Involved in choline metabolic process and lipid metabolic process. Located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
440 residues, UniProt reviewed canonical sequence.
>Q6UWR7|ENPP6
1 MAVKLGTLLL ALALGLAQPA SARRKLLVFL LDGFRSDYIS DEALESLPGF KEIVSRGVKV
61 DYLTPDFPSL SYPNYYTLMT GRHCEVHQMI GNYMWDPTTN KSFDIGVNKD SLMPLWWNGS
121 EPLWVTLTKA KRKVYMYYWP GCEVEILGVR PTYCLEYKNV PTDINFANAV SDALDSFKSG
181 RADLAAIYHE RIDVEGHHYG PASPQRKDAL KAVDTVLKYM TKWIQERGLQ DRLNVIIFSD
241 HGMTDIFWMD KVIELNKYIS LNDLQQVKDR GPVVSLWPAP GKHSEIYNKL STVEHMTVYE
301 KEAIPSRFYY KKGKFVSPLT LVADEGWFIT ENREMLPFWM NSTGRREGWQ RGWHGYDNEL
361 MDMRGIFLAF GPDFKSNFRA APIRSVDVYN VMCNVVGITP LPNNGSWSRV MCMLKGRAST
421 APPVWPSHCA LALILLFLLALocalizationUniProt · AlphaFold · HPA
Whether an antibody against ENPP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.26
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- kidney: 29 nTPM
- spinal cord: 28 nTPM
- ovary: 15 nTPM
- midbrain: 9.1 nTPM
- epididymis: 5.8 nTPM
- seminal vesicle: 5.7 nTPM
Single-cell type
- proximal tubule cells: 118 nCPM
- oligodendrocytes: 110 nCPM
- peritubular myoid cells: 52 nCPM
- pituitary stem cells: 47 nCPM
- epididymal principal cells: 19 nCPM
- fibroblasts: 17 nCPM
Immune cell
- basophil: 0.3 nTPM
- neutrophil: 0.2 nTPM
- NK-cell: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- eosinophil: 0.1 nTPM
- memory B-cell: 0.1 nTPM
Brain region
- white matter: 62 nTPM
- medulla oblongata: 46 nTPM
- pons: 34 nTPM
- cerebellum: 32 nTPM
- spinal cord: 29 nTPM
- basal ganglia: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.18
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.31
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- glycerophosphodiester phosphodiesterase activity
- metal ion binding
- phosphoric diester hydrolase activity
- glycerophosphocholine cholinephosphodiesterase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ENPP6 as an antibody target. Whether an autoantibody or antibody against ENPP6 could matter depends on whether native ENPP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ENPP6 is annotated at the cell surface, where native ENPP6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label ENPP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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