Seroatlas · Human Serome Atlas

ARSG

Arylsulfatase G

Also known as: ARSG_HUMAN, KIAA1001

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EG1
Gene: ARSG
Ensembl: ENSG00000141337
Chromosome: 17
Canonical length: 525 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q96EG1|ARSG
     1  MGWLFLKVLL AGVSFSGFLY PLVDFCISGK TRGQKPNFVI ILADDMGWGD LGANWAETKD
    61  TANLDKMASE GMRFVDFHAA ASTCSPSRAS LLTGRLGLRN GVTRNFAVTS VGGLPLNETT
   121  LAEVLQQAGY VTGIIGKWHL GHHGSYHPNF RGFDYYFGIP YSHDMGCTDT PGYNHPPCPA
   181  CPQGDGPSRN LQRDCYTDVA LPLYENLNIV EQPVNLSSLA QKYAEKATQF IQRASTSGRP
   241  FLLYVALAHM HVPLPVTQLP AAPRGRSLYG AGLWEMDSLV GQIKDKVDHT VKENTFLWFT
   301  GDNGPWAQKC ELAGSVGPFT GFWQTRQGGS PAKQTTWEGG HRVPALAYWP GRVPVNVTST
   361  ALLSVLDIFP TVVALAQASL PQGRRFDGVD VSEVLFGRSQ PGHRVLFHPN SGAAGEFGAL
   421  QTVRLERYKA FYITGGARAC DGSTGPELQH KFPLIFNLED DTAEAVPLER GGAEYQAVLP
   481  EVRKVLADVL QDIANDNISS ADYTQDPSVT PCCNPYQIAC RCQAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARSG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

epididymis: 29 nTPM
choroid plexus: 13 nTPM
retina: 7.2 nTPM
thyroid gland: 7 nTPM
fallopian tube: 6.2 nTPM
cerebellum: 5.9 nTPM

Single-cell type

neutrophils: 287 nCPM
choroid plexus epithelial cells: 175 nCPM
rod photoreceptor cells: 161 nCPM
epididymal principal cells: 117 nCPM
monocytes: 114 nCPM
retinal ganglion cells: 108 nCPM

Immune cell

neutrophil: 13 nTPM
classical monocyte: 8.5 nTPM
myeloid DC: 7.7 nTPM
basophil: 7 nTPM
eosinophil: 6.5 nTPM
gdT-cell: 6.3 nTPM

Brain region

choroid plexus: 24 nTPM
cerebellum: 19 nTPM
midbrain: 13 nTPM
pons: 13 nTPM
hypothalamus: 12 nTPM
medulla oblongata: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARSG.

Disease | AllUniProt

Conditions ARSG is implicated in, by any mechanism.

Usher syndrome 4 (USH4) MIM:618144

Disease | GeneticClinVar

44 pathogenic / likely-pathogenic of 460 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Usher syndrome, type 4
Usher syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

arylsulfatase activity
metal ion binding
N-sulfoglucosamine-3-sulfatase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARSG as an antibody target. Whether an autoantibody or antibody against ARSG could matter depends on whether native ARSG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARSG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARSG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...