Seroatlas · Human Serome Atlas

ARSI

Arylsulfatase I

Also known as: ARSI_HUMAN, FLJ16069, SPG66

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5FYB1
Gene
ARSI
Ensembl
ENSG00000183876
Chromosome
5
Canonical length
569 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q5FYB1|ARSI
     1  MHTLTGFSLV SLLSFGYLSW DWAKPSFVAD GPGEAGEQPS AAPPQPPHII FILTDDQGYH
    61  DVGYHGSDIE TPTLDRLAAK GVKLENYYIQ PICTPSRSQL LTGRYQIHTG LQHSIIRPQQ
   121  PNCLPLDQVT LPQKLQEAGY STHMVGKWHL GFYRKECLPT RRGFDTFLGS LTGNVDYYTY
   181  DNCDGPGVCG FDLHEGENVA WGLSGQYSTM LYAQRASHIL ASHSPQRPLF LYVAFQAVHT
   241  PLQSPREYLY RYRTMGNVAR RKYAAMVTCM DEAVRNITWA LKRYGFYNNS VIIFSSDNGG
   301  QTFSGGSNWP LRGRKGTYWE GGVRGLGFVH SPLLKRKQRT SRALMHITDW YPTLVGLAGG
   361  TTSAADGLDG YDVWPAISEG RASPRTEILH NIDPLYNHAQ HGSLEGGFGI WNTAVQAAIR
   421  VGEWKLLTGD PGYGDWIPPQ TLATFPGSWW NLERMASVRQ AVWLFNISAD PYEREDLAGQ
   481  RPDVVRTLLA RLAEYNRTAI PVRYPAENPR AHPDFNGGAW GPWASDEEEE EEEGRARSFS
   541  RGRRKKKCKI CKLRSFFRKL NTRLMSQRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARSI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
4.6 nTPM

Expression across tissuesHPA

Tissue

  • skin: 4.6 nTPM
  • lung: 4.3 nTPM
  • spinal cord: 4.2 nTPM
  • endometrium: 3.1 nTPM
  • urinary bladder: 2.9 nTPM
  • placenta: 2.6 nTPM

Single-cell type

  • proximal tubule cells: 35 nCPM
  • mast cells: 35 nCPM
  • melanocytes: 29 nCPM
  • hepatic stellate cells: 26 nCPM
  • pdcs: 25 nCPM
  • basal keratinocytes: 18 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 10 nTPM
  • pons: 7.7 nTPM
  • medulla oblongata: 7 nTPM
  • thalamus: 5 nTPM
  • basal ganglia: 4.7 nTPM
  • spinal cord: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
0.85
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARSI as an antibody target. Whether an autoantibody or antibody against ARSI could matter depends on whether native ARSI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARSI is annotated as secreted, so native ARSI circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ARSI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARSI. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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