Seroatlas · Human Serome Atlas

ARSB

Arylsulfatase B

Also known as: ARSB_HUMAN, ASB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15848
Gene
ARSB
Ensembl
ENSG00000113273
Chromosome
5
Canonical length
533 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Golgi apparatus
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

533 residues, UniProt reviewed canonical sequence.

>P15848|ARSB
     1  MGPRGAASLP RGPGPRRLLL PVVLPLLLLL LLAPPGSGAG ASRPPHLVFL LADDLGWNDV
    61  GFHGSRIRTP HLDALAAGGV LLDNYYTQPL CTPSRSQLLT GRYQIRTGLQ HQIIWPCQPS
   121  CVPLDEKLLP QLLKEAGYTT HMVGKWHLGM YRKECLPTRR GFDTYFGYLL GSEDYYSHER
   181  CTLIDALNVT RCALDFRDGE EVATGYKNMY STNIFTKRAI ALITNHPPEK PLFLYLALQS
   241  VHEPLQVPEE YLKPYDFIQD KNRHHYAGMV SLMDEAVGNV TAALKSSGLW NNTVFIFSTD
   301  NGGQTLAGGN NWPLRGRKWS LWEGGVRGVG FVASPLLKQK GVKNRELIHI SDWLPTLVKL
   361  ARGHTNGTKP LDGFDVWKTI SEGSPSPRIE LLHNIDPNFV DSSPCPRNSM APAKDDSSLP
   421  EYSAFNTSVH AAIRHGNWKL LTGYPGCGYW FPPPSQYNVS EIPSSDPPTK TLWLFDIDRD
   481  PEERHDLSRE YPHIVTKLLS RLQFYHKHSV PVYFPAQDPR CDPKATGVWG PWM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARSB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 20 nTPM
  • smooth muscle: 13 nTPM
  • placenta: 11 nTPM
  • blood vessel: 8.5 nTPM
  • heart muscle: 7.8 nTPM
  • bone marrow: 7.7 nTPM

Single-cell type

  • proximal tubule cells: 233 nCPM
  • microglia: 145 nCPM
  • neutrophil progenitors: 139 nCPM
  • kupffer cells: 134 nCPM
  • oligodendrocyte progenitor cells: 134 nCPM
  • macrophages: 126 nCPM

Immune cell

  • eosinophil: 26 nTPM
  • basophil: 19 nTPM
  • classical monocyte: 8.3 nTPM
  • myeloid DC: 7.8 nTPM
  • intermediate monocyte: 6.7 nTPM
  • non-classical monocyte: 5.7 nTPM

Brain region

  • thalamus: 22 nTPM
  • midbrain: 22 nTPM
  • white matter: 20 nTPM
  • cerebral cortex: 20 nTPM
  • medulla oblongata: 20 nTPM
  • hippocampal formation: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARSB.

Disease | AllUniProt

Conditions ARSB is implicated in, by any mechanism.

Disease | GeneticClinVar

258 pathogenic / likely-pathogenic of 1,028 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
0.63
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARSB as an antibody target. Whether an autoantibody or antibody against ARSB could matter depends on whether native ARSB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARSB is annotated at the cell surface, where native ARSB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARSB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARSB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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