Seroatlas · Human Serome Atlas

STS

Steryl-sulfatase

Also known as: STS_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P08842
Gene: STS
Canonical length: 583 aa
Protein class: Human disease related genes, Metabolic proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for STS in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>P08842|STS
     1  MPLRKMKIPF LLLFFLWEAE SHAASRPNII LVMADDLGIG DPGCYGNKTI RTPNIDRLAS
    61  GGVKLTQHLA ASPLCTPSRA AFMTGRYPVR SGMASWSRTG VFLFTASSGG LPTDEITFAK
   121  LLKDQGYSTA LIGKWHLGMS CHSKTDFCHH PLHHGFNYFY GISLTNLRDC KPGEGSVFTT
   181  GFKRLVFLPL QIVGVTLLTL AALNCLGLLH VPLGVFFSLL FLAALILTLF LGFLHYFRPL
   241  NCFMMRNYEI IQQPMSYDNL TQRLTVEAAQ FIQRNTETPF LLVLSYLHVH TALFSSKDFA
   301  GKSQHGVYGD AVEEMDWSVG QILNLLDELR LANDTLIYFT SDQGAHVEEV SSKGEIHGGS
   361  NGIYKGGKAN NWEGGIRVPG ILRWPRVIQA GQKIDEPTSN MDIFPTVAKL AGAPLPEDRI
   421  IDGRDLMPLL EGKSQRSDHE FLFHYCNAYL NAVRWHPQNS TSIWKAFFFT PNFNPVGSNG
   481  CFATHVCFCF GSYVTHHDPP LLFDISKDPR ERNPLTPASE PRFYEILKVM QEAADRHTQT
   541  LPEVPDQFSW NNFLWKPWLQ LCCPSTGLSC QCDREKQDKR LSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

placenta: 25 nTPM
adipose tissue: 17 nTPM
blood vessel: 13 nTPM
stomach: 11 nTPM
cerebral cortex: 9.1 nTPM
urinary bladder: 8.8 nTPM

Single-cell type

foveolar cells: 244 nCPM
syncytiotrophoblasts: 207 nCPM
cytotrophoblasts: 140 nCPM
prostatic glandular cells: 118 nCPM
respiratory ionocytes: 114 nCPM
migrating cytotrophoblasts: 112 nCPM

Immune cell

intermediate monocyte: 2 nTPM
classical monocyte: 1.7 nTPM
neutrophil: 1.3 nTPM
non-classical monocyte: 1.3 nTPM
myeloid DC: 0.9 nTPM
basophil: 0.8 nTPM

Brain region

thalamus: 47 nTPM
cerebral cortex: 46 nTPM
white matter: 37 nTPM
midbrain: 33 nTPM
pons: 33 nTPM
medulla oblongata: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STS.

Disease | AllUniProt

Conditions STS is implicated in, by any mechanism.

Ichthyosis, X-linked (IXL) MIM:308100

Disease | GeneticClinVar

21 pathogenic / likely-pathogenic of 252 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

X-linked ichthyosis with steryl-sulfatase deficiency
STS-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.81
gnomAD missense Z: 1.09
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STS as an antibody target. Whether an autoantibody or antibody against STS could matter depends on whether native STS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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