Seroatlas · Human Serome Atlas

ARSF

Arylsulfatase F

Also known as: ARSF_HUMAN, ASF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P54793
Gene: ARSF
Ensembl: ENSG00000062096
Chromosome: X
Canonical length: 590 aa
Protein class: Enzymes, Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Vesicles,Cytosol
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene is a member of the sulfatase family, and more specifically, the arylsulfatase subfamily. Members of the subfamily share similarity in sequence and splice sites, and are clustered together on chromosome X, suggesting that they are derived from recent gene duplication events. Sulfatases are essential for the correct composition of bone and cartilage matrix. The activity of this protein, unlike that of arylsulfatase E, is not inhibited by warfarin. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

590 residues, UniProt reviewed canonical sequence.

>P54793|ARSF
     1  MRPRRPLVFM SLVCALLNTC QAHRVHDDKP NIVLIMVDDL GIGDLGCYGN DTMRTPHIDR
    61  LAREGVRLTQ HISAASLCSP SRSAFLTGRY PIRSGMVSSG NRRVIQNLAV PAGLPLNETT
   121  LAALLKKQGY STGLIGKWHQ GLNCDSRSDQ CHHPYNYGFD YYYGMPFTLV DSCWPDPSRN
   181  TELAFESQLW LCVQLVAIAI LTLTFGKLSG WVSVPWLLIF SMILFIFLLG YAWFSSHTSP
   241  LYWDCLLMRG HEITEQPMKA ERAGSIMVKE AISFLERHSK ETFLLFFSFL HVHTPLPTTD
   301  DFTGTSKHGL YGDNVEEMDS MVGKILDAID DFGLRNNTLV YFTSDHGGHL EARRGHAQLG
   361  GWNGIYKGGK GMGGWEGGIR VPGIVRWPGK VPAGRLIKEP TSLMDILPTV ASVSGGSLPQ
   421  DRVIDGRDLM PLLQGNVRHS EHEFLFHYCG SYLHAVRWIP KDDSGSVWKA HYVTPVFQPP
   481  ASGGCYVTSL CRCFGEQVTY HNPPLLFDLS RDPSESTPLT PATEPLHDFV IKKVANALKE
   541  HQETIVPVTY QLSELNQGRT WLKPCCGVFP FCLCDKEEEV SQPRGPNEKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARSF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 7.1 nTPM

Expression across tissuesHPA

Tissue

kidney: 7.1 nTPM
skin: 5.3 nTPM
basal ganglia: 4.8 nTPM
adrenal gland: 2.8 nTPM
amygdala: 2.6 nTPM
esophagus: 2.4 nTPM

Single-cell type

adrenal medulla cells: 43 nCPM
proximal tubule cells: 38 nCPM
astrocytes: 21 nCPM
esophageal apical cells: 11 nCPM
esophageal suprabasal cells: 9.7 nCPM
oligodendrocyte progenitor cells: 5.2 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 8.3 nTPM
basal ganglia: 5.5 nTPM
hippocampal formation: 4.7 nTPM
pons: 4.5 nTPM
cerebellum: 4.4 nTPM
thalamus: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: -0.39
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARSF as an antibody target. Whether an autoantibody or antibody against ARSF could matter depends on whether native ARSF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARSF is annotated as secreted, so native ARSF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ARSF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...