Seroatlas · Human Serome Atlas

SULF2

Extracellular sulfatase Sulf-2

Also known as: HSULF-2, KIAA1247, SULF-2, SULF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IWU5
Gene
SULF2
Ensembl
ENSG00000196562
Chromosome
20
Canonical length
870 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

870 residues, UniProt reviewed canonical sequence.

>Q8IWU5|SULF2
     1  MGPPSLVLCL LSATVFSLLG GSSAFLSHHR LKGRFQRDRR NIRPNIILVL TDDQDVELGS
    61  MQVMNKTRRI MEQGGAHFIN AFVTTPMCCP SRSSILTGKY VHNHNTYTNN ENCSSPSWQA
   121  QHESRTFAVY LNSTGYRTAF FGKYLNEYNG SYVPPGWKEW VGLLKNSRFY NYTLCRNGVK
   181  EKHGSDYSKD YLTDLITNDS VSFFRTSKKM YPHRPVLMVI SHAAPHGPED SAPQYSRLFP
   241  NASQHITPSY NYAPNPDKHW IMRYTGPMKP IHMEFTNMLQ RKRLQTLMSV DDSMETIYNM
   301  LVETGELDNT YIVYTADHGY HIGQFGLVKG KSMPYEFDIR VPFYVRGPNV EAGCLNPHIV
   361  LNIDLAPTIL DIAGLDIPAD MDGKSILKLL DTERPVNRFH LKKKMRVWRD SFLVERGKLL
   421  HKRDNDKVDA QEENFLPKYQ RVKDLCQRAE YQTACEQLGQ KWQCVEDATG KLKLHKCKGP
   481  MRLGGSRALS NLVPKYYGQG SEACTCDSGD YKLSLAGRRK KLFKKKYKAS YVRSRSIRSV
   541  AIEVDGRVYH VGLGDAAQPR NLTKRHWPGA PEDQDDKDGG DFSGTGGLPD YSAANPIKVT
   601  HRCYILENDT VQCDLDLYKS LQAWKDHKLH IDHEIETLQN KIKNLREVRG HLKKKRPEEC
   661  DCHKISYHTQ HKGRLKHRGS SLHPFRKGLQ EKDKVWLLRE QKRKKKLRKL LKRLQNNDTC
   721  SMPGLTCFTH DNQHWQTAPF WTLGPFCACT SANNNTYWCM RTINETHNFL FCEFATGFLE
   781  YFDLNTDPYQ LMNAVNTLDR DVLNQLHVQL MELRSCKGYK QCNPRTRNMD LGLKDGGSYE
   841  QYRQFQRRKW PEMKRPSSKS LGQLWEGWEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
148 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 148 nTPM
  • cervix: 87 nTPM
  • endometrium: 84 nTPM
  • smooth muscle: 82 nTPM
  • esophagus: 63 nTPM
  • gallbladder: 53 nTPM

Single-cell type

  • pdcs: 511 nCPM
  • podocytes: 423 nCPM
  • oligodendrocyte progenitor cells: 362 nCPM
  • endometrial stromal cells: 355 nCPM
  • neutrophils: 321 nCPM
  • cdc: 316 nCPM

Immune cell

  • neutrophil: 26 nTPM
  • plasmacytoid DC: 26 nTPM
  • basophil: 22 nTPM
  • myeloid DC: 20 nTPM
  • classical monocyte: 17 nTPM
  • intermediate monocyte: 16 nTPM

Brain region

  • pons: 89 nTPM
  • midbrain: 84 nTPM
  • medulla oblongata: 74 nTPM
  • hippocampal formation: 68 nTPM
  • hypothalamus: 63 nTPM
  • cerebral cortex: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.01
gnomAD missense Z
1.72
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULF2 as an antibody target. Whether an autoantibody or antibody against SULF2 could matter depends on whether native SULF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULF2 is annotated at the cell surface, where native SULF2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SULF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SULF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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