Seroatlas · Human Serome Atlas

ARSJ

Arylsulfatase J

Also known as: ARSJ_HUMAN, FLJ23548

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5FYB0
Gene: ARSJ
Ensembl: ENSG00000180801
Chromosome: 4
Canonical length: 599 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Actin filaments
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

599 residues, UniProt reviewed canonical sequence.

>Q5FYB0|ARSJ
     1  MAPRGCAGHP PPPSPQACVC PGKMLAMGAL AGFWILCLLT YGYLSWGQAL EEEEEGALLA
    61  QAGEKLEPST TSTSQPHLIF ILADDQGFRD VGYHGSEIKT PTLDKLAAEG VKLENYYVQP
   121  ICTPSRSQFI TGKYQIHTGL QHSIIRPTQP NCLPLDNATL PQKLKEVGYS THMVGKWHLG
   181  FYRKECMPTR RGFDTFFGSL LGSGDYYTHY KCDSPGMCGY DLYENDNAAW DYDNGIYSTQ
   241  MYTQRVQQIL ASHNPTKPIF LYIAYQAVHS PLQAPGRYFE HYRSIININR RRYAAMLSCL
   301  DEAINNVTLA LKTYGFYNNS IIIYSSDNGG QPTAGGSNWP LRGSKGTYWE GGIRAVGFVH
   361  SPLLKNKGTV CKELVHITDW YPTLISLAEG QIDEDIQLDG YDIWETISEG LRSPRVDILH
   421  NIDPIYTKAK NGSWAAGYGI WNTAIQSAIR VQHWKLLTGN PGYSDWVPPQ SFSNLGPNRW
   481  HNERITLSTG KSVWLFNITA DPYERVDLSN RYPGIVKKLL RRLSQFNKTA VPVRYPPKDP
   541  RSNPRLNGGV WGPWYKEETK KKKPSKNQAE KKQKKSKKKK KKQQKAVSGS TCHSGVTCG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARSJ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 5.5 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 5.5 nTPM
blood vessel: 5.1 nTPM
cervix: 4.2 nTPM
placenta: 4 nTPM
prostate: 3.6 nTPM
urinary bladder: 3.6 nTPM

Single-cell type

renal collecting duct intercalated cells: 166 nCPM
salivary ionocytes: 131 nCPM
alveolar cells type 1: 110 nCPM
renal connecting tubule cells: 101 nCPM
endometrial stromal cells: 85 nCPM
renal collecting duct principal cells: 84 nCPM

Immune cell

MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 11 nTPM
thalamus: 4.1 nTPM
basal ganglia: 3.1 nTPM
cerebral cortex: 2.9 nTPM
midbrain: 2.6 nTPM
white matter: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 1.69
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARSJ as an antibody target. Whether an autoantibody or antibody against ARSJ could matter depends on whether native ARSJ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARSJ is annotated as secreted, so native ARSJ circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ARSJ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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