Seroatlas · Human Serome Atlas

ENPP7

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

Also known as: alk-SMase, ENPP7_HUMAN, NPP7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWV6
Gene: ENPP7
Ensembl: ENSG00000182156
Chromosome: 17
Canonical length: 458 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q6UWV6|ENPP7
     1  MRGPAVLLTV ALATLLAPGA GAPVQSQGSQ NKLLLVSFDG FRWNYDQDVD TPNLDAMARD
    61  GVKARYMTPA FVTMTSPCHF TLVTGKYIEN HGVVHNMYYN TTSKVKLPYH ATLGIQRWWD
   121  NGSVPIWITA QRQGLRAGSF FYPGGNVTYQ GVAVTRSRKE GIAHNYKNET EWRANIDTVM
   181  AWFTEEDLDL VTLYFGEPDS TGHRYGPESP ERREMVRQVD RTVGYLRESI ARNHLTDRLN
   241  LIITSDHGMT TVDKRAGDLV EFHKFPNFTF RDIEFELLDY GPNGMLLPKE GRLEKVYDAL
   301  KDAHPKLHVY KKEAFPEAFH YANNPRVTPL LMYSDLGYVI HGRINVQFNN GEHGFDNKDM
   361  DMKTIFRAVG PSFRAGLEVE PFESVHVYEL MCRLLGIVPE ANDGHLATLL PMLHTESALP
   421  PDGRPTLLPK GRSALPPSSR PLLVMGLLGT VILLSEVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENPP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

small intestine: 99 nTPM
duodenum: 43 nTPM
liver: 11 nTPM
kidney: 4.1 nTPM
appendix: 0.1 nTPM
spleen: 0.1 nTPM

Single-cell type

enterocytes: 27 nCPM
hepatocytes: 14 nCPM
proximal tubule cells: 3.1 nCPM
b-cells: 1 nCPM
pancreatic duct cells: 0.6 nCPM
plasma cells: 0.5 nCPM

Immune cell

memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 0.4 nTPM
cerebral cortex: 0.3 nTPM
medulla oblongata: 0.3 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM
midbrain: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: -0.48
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENPP7 as an antibody target. Whether an autoantibody or antibody against ENPP7 could matter depends on whether native ENPP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENPP7 is annotated at the cell surface, where native ENPP7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ENPP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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