MGA

Protein identityUniProt · HPA

UniProt accession

Q8IWI9

Gene

MGA

Ensembl

ENSG00000174197

Chromosome

15

Canonical length

3065 aa

Protein class

Cancer-related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Part of MLL1 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

3065 residues, UniProt reviewed canonical sequence.

>Q8IWI9|MGA
     1  MEEKQQIILA NQDGGTVAGA APTFFVILKQ PGNGKTDQGI LVTNQDACAL ASSVSSPVKS
    61  KGKICLPADC TVGGITVTLD NNSMWNEFYH RSTEMILTKQ GRRMFPYCRY WITGLDSNLK
   121  YILVMDISPV DNHRYKWNGR WWEPSGKAEP HVLGRVFIHP ESPSTGHYWM HQPVSFYKLK
   181  LTNNTLDQEG HIILHSMHRY LPRLHLVPAE KAVEVIQLNG PGVHTFTFPQ TEFFAVTAYQ
   241  NIQITQLKID YNPFAKGFRD DGLNNKPQRD GKQKNSSDQE GNNISSSSGH RVRLTEGQGS
   301  EIQPGDLDPL SRGHETSGKG LEKTSLNIKR DFLGFMDTDS ALSEVPQLKQ EISECLIASS
   361  FEDDSRVASP LDQNGSFNVV IKEEPLDDYD YELGECPEGV TVKQEETDEE TDVYSNSDDD
   421  PILEKQLKRH NKVDNPEADH LSSKWLPSSP SGVAKAKMFK LDTGKMPVVY LEPCAVTRST
   481  VKISELPDNM LSTSRKDKSS MLAELEYLPT YIENSNETAF CLGKESENGL RKHSPDLRVV
   541  QKYPLLKEPQ WKYPDISDSI STERILDDSK DSVGDSLSGK EDLGRKRTTM LKIATAAKVV
   601  NANQNASPNV PGKRGRPRKL KLCKAGRPPK NTGKSLISTK NTPVSPGSTF PDVKPDLEDV
   661  DGVLFVSFES KEALDIHAVD GTTEESSSLQ ASTTNDSGYR ARISQLEKEL IEDLKTLRHK
   721  QVIHPGLQEV GLKLNSVDPT MSIDLKYLGV QLPLAPATSF PFWNLTGTNP ASPDAGFPFV
   781  SRTGKTNDFT KIKGWRGKFH SASASRNEGG NSESSLKNRS AFCSDKLDEY LENEGKLMET
   841  SMGFSSNAPT SPVVYQLPTK STSYVRTLDS VLKKQSTISP STSYSLKPHS VPPVSRKAKS
   901  QNRQATFSGR TKSSYKSILP YPVSPKQKYS HVILGDKVTK NSSGIISENQ ANNFVVPTLD
   961  ENIFPKQISL RQAQQQQQQQ QGSRPPGLSK SQVKLMDLED CALWEGKPRT YITEERADVS
  1021  LTTLLTAQAS LKTKPIHTII RKRAPPCNND FCRLGCVCSS LALEKRQPAH CRRPDCMFGC
  1081  TCLKRKVVLV KGGSKTKHFQ RKAAHRDPVF YDTLGEEARE EEEGIREEEE QLKEKKKRKK
  1141  LEYTICETEP EQPVRHYPLW VKVEGEVDPE PVYIPTPSVI EPMKPLLLPQ PEVLSPTVKG
  1201  KLLTGIKSPR SYTPKPNPVI REEDKDPVYL YFESMMTCAR VRVYERKKED QRQPSSSSSP
  1261  SPSFQQQTSC HSSPENHNNA KEPDSEQQPL KQLTCDLEDD SDKLQEKSWK SSCNEGESSS
  1321  TSYMHQRSPG GPTKLIEIIS DCNWEEDRNK ILSILSQHIN SNMPQSLKVG SFIIELASQR
  1381  KSRGEKNPPV YSSRVKISMP SCQDQDDMAE KSGSETPDGP LSPGKMEDIS PVQTDALDSV
  1441  RERLHGGKGL PFYAGLSPAG KLVAYKRKPS SSTSGLIQVA SNAKVAASRK PRTLLPSTSN
  1501  SKMASSSGTA TNRPGKNLKA FVPAKRPIAA RPSPGGVFTQ FVMSKVGALQ QKIPGVSTPQ
  1561  TLAGTQKFSI RPSPVMVVTP VVSSEPVQVC SPVTAAVTTT TPQVFLENTT AVTPMTAISD
  1621  VETKETTYSS GATTTGVVEV SETNTSTSVT STQSTATVNL TKTTGITTPV ASVAFPKSLV
  1681  ASPSTITLPV ASTASTSLVV VTAAASSSMV TTPTSSLGSV PIILSGINGS PPVSQRPENA
  1741  AQIPVATPQV SPNTVKRAGP RLLLIPVQQG SPTLRPVSNT QLQGHRMVLQ PVRSPSGMNL
  1801  FRHPNGQIVQ LLPLHQLRGS NTQPNLQPVM FRNPGSVMGI RLPAPSKPSE TPPSSTSSSA
  1861  FSVMNPVIQA VGSSSAVNVI TQAPSLLSSG ASFVSQAGTL TLRISPPEPQ SFASKTGSET
  1921  KITYSSGGQP VGTASLIPLQ SGSFALLQLP GQKPVPSSIL QHVASLQMKR ESQNPDQKDE
  1981  TNSIKREQET KKVLQSEGEA VDPEANVIKQ NSGAATSEET LNDSLEDRGD HLDEECLPEE
  2041  GCATVKPSEH SCITGSHTDQ DYKDVNEEYG ARNRKSSKEK VAVLEVRTIS EKASNKTVQN
  2101  LSKVQHQKLG DVKVEQQKGF DNPEENSSEF PVTFKEESKF ELSGSKVMEQ QSNLQPEAKE
  2161  KECGDSLEKD RERWRKHLKG PLTRKCVGAS QECKKEADEQ LIKETKTCQE NSDVFQQEQG
  2221  ISDLLGKSGI TEDARVLKTE CDSWSRISNP SAFSIVPRRA AKSSRGNGHF QGHLLLPGEQ
  2281  IQPKQEKKGG RSSADFTVLD LEEDDEDDNE KTDDSIDEIV DVVSDYQSEE VDDVEKNNCV
  2341  EYIEDDEEHV DIETVEELSE EINVAHLKTT AAHTQSFKQP SCTHISADEK AAERSRKAPP
  2401  IPLKLKPDYW SDKLQKEAEA FAYYRRTHTA NERRRRGEMR DLFEKLKITL GLLHSSKVSK
  2461  SLILTRAFSE IQGLTDQADK LIGQKNLLTR KRNILIRKVS SLSGKTEEVV LKKLEYIYAK
  2521  QQALEAQKRK KKMGSDEFDI SPRISKQQEG SSASSVDLGQ MFINNRRGKP LILSRKKDQA
  2581  TENTSPLNTP HTSANLVMTP QGQLLTLKGP LFSGPVVAVS PDLLESDLKP QVAGSAVALP
  2641  ENDDLFMMPR IVNVTSLATE GGLVDMGGSK YPHEVPDSKP SDHLKDTVRN EDNSLEDKGR
  2701  ISSRGNRDGR VTLGPTQVFL ANKDSGYPQI VDVSNMQKAQ EFLPKKISGD MRGIQYKWKE
  2761  SESRGERVKS KDSSFHKLKM KDLKDSSIEM ELRKVTSAIE EAALDSSELL TNMEDEDDTD
  2821  ETLTSLLNEI AFLNQQLNDD SVGLAELPSS MDTEFPGDAR RAFISKVPPG SRATFQVEHL
  2881  GTGLKELPDV QGESDSISPL LLHLEDDDFS ENEKQLAEPA SEPDVLKIVI DSEIKDSLLS
  2941  NKKAIDGGKN TSGLPAEPES VSSPPTLHMK TGLENSNSTD TLWRPMPKLA PLGLKVANPS
  3001  SDADGQSLKV MPCLAPIAAK VGSVGHKMNL TGNDQEGRES KVMPTLAPVV AKLGNSGASP
  3061  SSAGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MGA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

7.7 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MGA.

Disease | AllUniProt

Conditions MGA is implicated in, by any mechanism.

• Premature ovarian failure 26 (POF26) MIM:621065

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 97 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Premature ovarian failure 26
• Multiple myeloma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.09

gnomAD pLI

1

gnomAD missense Z

1.1

DepMap mean gene effect

-0.21

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell fate specification
• positive regulation of DNA-templated transcription
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• protein dimerization activity
• RNA polymerase II cis-regulatory region sequence-specific DNA binding

Cellular components

• chromatin
• MLL1 complex
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• T-box transcription factor
• p53-like transcription factor, DNA-binding domain superfamily
• Myc-type, basic helix-loop-helix (bHLH) domain
• Transcription factor, T-box, conserved site
• Helix-loop-helix DNA-binding domain superfamily
• T-box superfamily
• T-box transcription factor, DNA-binding domain
• Helix-loop-helix DNA-binding domain
• T-box
• MGA, conserved domain
• MAX gene-associated protein, basic Helix-Loop-Helix-zipper domain
• MGA, conserved domain

KeywordsUniProt

• Coiled coil
• DNA-binding
• Isopeptide bond
• Methylation
• Nucleus
• Phosphoprotein
• Premature ovarian failure
• Repressor
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of MGA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAX
• ZMYND11
• CBX3