Seroatlas · Human Serome Atlas

EOMES

Eomesodermin homolog

Also known as: EOMES_HUMAN, TBR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95936
Gene
EOMES
Ensembl
ENSG00000163508
Chromosome
3
Canonical length
686 aa
Protein class
Disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>O95936|EOMES
     1  MQLGEQLLVS SVNLPGAHFY PLESARGGSG GSAGHLPSAA PSPQKLDLDK ASKKFSGSLS
    61  CEAVSGEPAA ASAGAPAAML SDTDAGDAFA SAAAVAKPGP PDGRKGSPCG EEELPSAAAA
   121  AAAAAAAAAA TARYSMDSLS SERYYLQSPG PQGSELAAPC SLFPYQAAAG APHGPVYPAP
   181  NGARYPYGSM LPPGGFPAAV CPPGRAQFGP GAGAGSGAGG SSGGGGGPGT YQYSQGAPLY
   241  GPYPGAAAAG SCGGLGGLGV PGSGFRAHVY LCNRPLWLKF HRHQTEMIIT KQGRRMFPFL
   301  SFNINGLNPT AHYNVFVEVV LADPNHWRFQ GGKWVTCGKA DNNMQGNKMY VHPESPNTGS
   361  HWMRQEISFG KLKLTNNKGA NNNNTQMIVL QSLHKYQPRL HIVEVTEDGV EDLNEPSKTQ
   421  TFTFSETQFI AVTAYQNTDI TQLKIDHNPF AKGFRDNYDS SHQIVPGGRY GVQSFFPEPF
   481  VNTLPQARYY NGERTVPQTN GLLSPQQSEE VANPPQRWLV TPVQQPGTNK LDISSYESEY
   541  TSSTLLPYGI KSLPLQTSHA LGYYPDPTFP AMAGWGGRGS YQRKMAAGLP WTSRTSPTVF
   601  SEDQLSKEKV KEEIGSSWIE TPPSIKSLDS NDSGVYTSAC KRRRLSPSNS SNENSPSIKC
   661  EDINAEEYSK DTSKGMGGYY AFYTTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EOMES can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 15 nTPM
  • lymph node: 14 nTPM
  • spleen: 12 nTPM
  • tonsil: 5.1 nTPM
  • appendix: 3 nTPM
  • liver: 2.2 nTPM

Single-cell type

  • nk-cells: 68 nCPM
  • t-cells: 37 nCPM
  • retinal ganglion cells: 7.7 nCPM
  • brain excitatory neurons: 6.2 nCPM
  • innate lymphoid cells: 3.9 nCPM
  • cholangiocytes: 2 nCPM

Immune cell

  • NK-cell: 33 nTPM
  • MAIT T-cell: 26 nTPM
  • memory CD8 T-cell: 19 nTPM
  • gdT-cell: 17 nTPM
  • naive CD8 T-cell: 12 nTPM
  • memory CD4 T-cell: 3 nTPM

Brain region

  • cerebellum: 17 nTPM
  • pons: 1.2 nTPM
  • cerebral cortex: 0.7 nTPM
  • choroid plexus: 0.7 nTPM
  • white matter: 0.7 nTPM
  • hypothalamus: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
0.86
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EOMES as an antibody target. Whether an autoantibody or antibody against EOMES could matter depends on whether native EOMES is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EOMES is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EOMES as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EOMES. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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