Seroatlas · Human Serome Atlas

STAT5B

Signal transducer and activator of transcription 5B

Also known as: STA5B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51692
Gene: STAT5B
Ensembl: ENSG00000173757
Chromosome: 17
Canonical length: 787 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

787 residues, UniProt reviewed canonical sequence.

>P51692|STAT5B
     1  MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN PQENIKATQL
    61  LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV
   121  REANNGSSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL
   181  RIQAQFGPLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL
   241  RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC
   301  QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL
   361  NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS
   421  LKRIKRSDRR GAESVTEEKF TILFESQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA
   481  TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN
   541  SSSHLEDYSG LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK
   601  QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL
   661  GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV KPQIKQVVPE FVNASADAGG
   721  GSATYMDQAP SPAVCPQAHY NMYPQNPDSV LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ
   781  WIPHAQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAT5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 65 nTPM
endometrium: 56 nTPM
ovary: 54 nTPM
fallopian tube: 50 nTPM
cerebellum: 48 nTPM
adrenal gland: 44 nTPM

Single-cell type

neutrophils: 1,498 nCPM
peritubular myoid cells: 294 nCPM
late spermatids: 286 nCPM
neutrophil progenitors: 250 nCPM
leydig cells: 247 nCPM
t-cells: 236 nCPM

Immune cell

neutrophil: 7.3 nTPM
basophil: 5.3 nTPM
T-reg: 3 nTPM
memory CD8 T-cell: 2.7 nTPM
MAIT T-cell: 2.5 nTPM
memory CD4 T-cell: 2.5 nTPM

Brain region

hypothalamus: 56 nTPM
midbrain: 33 nTPM
pons: 30 nTPM
medulla oblongata: 27 nTPM
thalamus: 27 nTPM
spinal cord: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STAT5B.

Disease | AllUniProt

Conditions STAT5B is implicated in, by any mechanism.

Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive (GHISID1) MIM:245590
Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant (GHISID2) MIM:618985

Disease | GeneticClinVar

32 pathogenic / likely-pathogenic of 603 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Growth hormone insensitivity with immune dysregulation 1, autosomal recessive
Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant
Familial prostate cancer

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 4
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAT5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAT5B as an antibody target. Whether an autoantibody or antibody against STAT5B could matter depends on whether native STAT5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAT5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAT5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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