RBPJL

Protein identityUniProt · HPA

UniProt accession

Q9UBG7

Gene

RBPJL

Ensembl

ENSG00000124232

Chromosome

20

Canonical length

517 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q9UBG7|RBPJL
     1  MDPAGAADPS VPPNPLTHLS LQDRSEMQLQ SEADRRSLPG TWTRSSPEHT TILRGGVRRC
    61  LQQQCEQTVR ILHAKVAQKS YGNEKRFFCP PPCVYLSGPG WRVKPGQDQA HQAGETGPTV
   121  CGYMGLDSAS GSATETQKLN FEQQPDSREF GCAKTLYISD ADKRKHFRLV LRLVLRGGRE
   181  LGTFHSRLIK VISKPSQKKQ SLKNTDLCIS SGSKVSLFNR LRSQTVSTRY LSVEDGAFVA
   241  SARQWAAFTL HLADGHSAQG DFPPREGYVR YGSLVQLVCT VTGITLPPMI IRKVAKQCAL
   301  LDVDEPISQL HKCAFQFPGS PPGGGGTYLC LATEKVVQFQ ASPCPKEANR ALLNDSSCWT
   361  IIGTESVEFS FSTSLACTLE PVTPVPLIST LELSGGGDVA TLELHGENFH AGLKVWFGDV
   421  EAETMYRSPR SLVCVVPDVA AFCSDWRWLR APITIPMSLV RADGLFYPSA FSFTYTPEYS
   481  VRPGHPGVPE PATDADALLE SIHQEFTRTN FHLFIQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBPJL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

920 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.08

gnomAD pLI

0

gnomAD missense Z

1.03

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• signal transduction

Molecular functions

• chromatin binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding

Cellular components

• chromatin
• nucleus
• transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• p53-like transcription factor, DNA-binding domain superfamily
• Immunoglobulin-like fold
• Immunoglobulin E-set
• Beta-trefoil DNA-binding domain
• RBP-J/Cbf11/Cbf12, DNA binding
• Beta-trefoil domain superfamily
• RBP-J/Cbf11, DNA binding domain superfamily
• RBP-Jkappa, IPT domain
• Suppressor of hairless-like
• Beta-trefoil DNA-binding domain
• LAG1, DNA binding
• TIG domain

KeywordsUniProt

• DNA-binding
• Nucleus
• Transcription
• Transcription regulation