Seroatlas · Human Serome Atlas

MYRFL

Myelin regulatory factor-like protein

Also known as: bcm1377, C12orf15, C12orf28, FLJ25056, MRFL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LU7
Gene: MYRFL
Ensembl: ENSG00000166268
Chromosome: 12
Canonical length: 910 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and protein autoprocessing. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

910 residues, UniProt reviewed canonical sequence.

>Q96LU7|MYRFL
     1  MDVVGENEAL QQFFEAQGAN GTLENPALDT SLLEEFLGND FDLGALQRQL PDTPPYSASD
    61  SCSPPQVKGA CYPTLRPTAG RTPAPFLHPT AAPAMPPMHP LQSTSGMGDS CQIHGGFHSC
   121  HSNASHLATP LDQSVSSHLG IGCSYPQQPL CHSPGASLPP TKKRKCTQAL EDSGECRVWA
   181  CHCRPMTSRS RSSEVQDPDS EGQNRMPTDQ CSPALKWQPC HSVPWHSLLN SHYEKLPDVG
   241  YRVVTDKGFN FSPADEAFVC QKKNHFQITI HIQVWGSPKF VETEMGLKPI EMFYLKVFGT
   301  KVEATNQIIA IEQSQADRSK KIFNPVKIDL LADQVTKVTL GRLHFSETTA NNMRKKGKPN
   361  PDQRYFMLVV GLYAANQDQF YLLSAHISER IIVRASNPGQ FENDSDALWQ RGQVPESIVC
   421  HGRVGINTDA PDEALVVCGN MKVMGTIMHP SDSRAKQNIQ EVDTNEQLKR IAQMRIVEYD
   481  YKPEFASAMG INTAHQTGMI AQEVQEILPR AVREVGDVTC GNGETLENFL MVDKDQIFME
   541  NVGAVKQLCK LTNNLEERIE ELEIWNRKLA RLKRLSSWKS SASEASTISK SSRAVSASSP
   601  RRAVHKKNNK VYFSGKRQAC PNWVFQTLVI TLIAVMAFCA LTIVALYILS LKDQDRRVPN
   661  LPPSNITSSQ EPALLPTASS SAPNTSLVTT PASLQVPEIT FCEILPCQET YCCPIRGMKE
   721  VSSSPVQRQS EEKEFHQRRW SEDKSKSVLA RNALSGPDWE SDWIDTTISS IQIMEIQQII
   781  DHQYCIQSLQ CGSGNYNYNI PVNKHTPTNV KFSLEINTTE PLIVFQCKFT LGNICFHSKR
   841  GTKGLESHRE ISQEMTQGYQ HIWSLPVAPF SDSMFHFRVA APDLADCSTD PYFAGIFFTD
   901  YFFYFYRRCA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYRFL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

duodenum: 22 nTPM
small intestine: 20 nTPM
blood vessel: 2.4 nTPM
testis: 2.3 nTPM
cerebellum: 1.8 nTPM
kidney: 1.8 nTPM

Single-cell type

retinal pigment epithelial cells: 188 nCPM
enterocytes: 180 nCPM
epididymal clear cells: 112 nCPM
renal connecting tubule cells: 95 nCPM
endometrial secretory cells: 84 nCPM
distal convoluted tubule cells: 81 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 6.4 nTPM
pons: 4.3 nTPM
hippocampal formation: 3.2 nTPM
hypothalamus: 3.2 nTPM
medulla oblongata: 3.1 nTPM
choroid plexus: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.78

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYRFL as an antibody target. Whether an autoantibody or antibody against MYRFL could matter depends on whether native MYRFL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYRFL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYRFL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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