Laminin-type EGF domain
IPR002049
Definition
This entry represents the laminin-type EGF-like domain (LE) found in Laminin subunit gamma-1 and Netrin-1 from Homo sapiens and Mus musculus. Laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation [[cite:PMID:2404817], [cite:PMID:23263635]]. They are composed of distinct but related alpha, beta and gamma chains that form a cross-shaped molecule consisting of a long arm and three short globular arms. The long arm has a coiled coil structure contributed by all three chains and cross-linked by interchain disulphide bonds [[cite:PMID:23263635], [cite:PMID:23263632]]. Beside the different types of globular domains each subunit contains, in its first half, consecutive repeats of about 60 amino acids in length that include eight conserved cysteines PMID:2666164. The tertiary structure of this domain is remotely similar in its N-terminal to that of the EGF-like module [[cite:PMID:8648630], [cite:PMID:8648631]] (see [prositedoc:PDOC00021]). The number of copies of the LE domain in the different forms of laminins is highly variable; from 3 up to 22 copies have been found. A schematic representation of the topology of the four disulphide bonds in the LE domain is shown below. +-------------------+ +-|-----------+ | +--------+ +-----------------+ | | | | | | | | xxCxCxxxxxxxxxxxCxxxxxxxCxxCxxxxxGxxCxxCxxgaagxxxxxxxxxxxCxx sssssssssssssssssssssssssssssssssss 'C': conserved cysteine involved in a disulphide bond 'a': conserved aromatic residue 'G': conserved glycine (lower case = less conserved) 's': region similar to the EGF-like domain Long consecutive arrays of LE domains in laminins form rod-like elements of limited flexibility PMID:2404817, which determine the spacing in the formation of laminin networks of basement membranes PMID:8349613. Netrins control guidance of the central nervous system commissural axons and peripheral motor axons [[cite:PMID:17174565], [cite:PMID:28483977], [cite:PMID:30224412], [cite:PMID:30108487]]. This protein also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis, thus being involved in tumorigenesis [[cite:PMID:15343335], [cite:PMID:30923634]].
41 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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