Seroatlas · Human Serome Atlas

MUC3A

Mucin-3A

Also known as: MUC3, MUC3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02505
Gene
MUC3A
Ensembl
ENSG00000169894
Chromosome
7
Canonical length
3323 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cell Junctions
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]

Canonical amino-acid sequenceUniProt

3323 residues, UniProt reviewed canonical sequence.

>Q02505|MUC3A
     1  MQLLGLLGLL WMLKASPWAT GTLSTATSIS QVPFPRAEAA SAVLSNSPHS RDLAGWPLGV
    61  PQLASPAPGH RENAPMTLTT SPHDTLISET LLNSPVSSNT STTPTSKFAF KVETTPPTVL
   121  VYSATTECVY PTSFIITISH PTSICVTTTQ VAFTSSYTST PVTQKPVTTV TSTYSMTTTE
   181  KGTSAMTSSP STTTARETPI VTVTPSSVSA TDTTFHTTIS STTRTTERTP LPTGSIHTTT
   241  SPTPVFTTLK TAVTSTSPIT SSITSTNTVT SMTTTASQPT ATNTLSSPTR TILSSTPVLS
   301  TETITSGITN TTPLSTLVTT LPTTISRSTP TSETTYTTSP TSTVTDSTTK IAYSTSMTGT
   361  LSTETSLPPT SSSLPTTETA TTPMTNLVTT TTEISSHSTP SFSSSTIYST VSTSTTAISS
   421  LPPTSGTMVT STTMTPSSLS TDIPFTTPTT ITHHSVGSTG FLTTATDLTS TFTVSSSSAM
   481  STSVIPSSPS IQNTETSSLV SMTSATTPNV RPTFVSTLST PTSSLLTTFP ATYSFSSSMS
   541  ASSAGTTHTE SISSPPASTS TLHTTAESTL APTTTTSFTT STTMEPPSTT AATTGTGQTT
   601  FTSSTATFPE TTTPTPTTDM STESLTTAMT SPPITSSVTS TNTVTSMTTT TSPPTTTNSF
   661  TSLTSMPLSS TPVPSTEVVT SGTINTIPPS ILVTTLPTPN ASSMTTSETT YPNSPTGPGT
   721  NSTTEITYPT TMTETSSTAT SLPPTSPLVS TAKTAKTPTT NLVTTTTKTT SHSTTSFTSS
   781  TVYSTASTYT TAITSVPTTL GTMVTSTSMI SSTVSTGIPT SQPTTITPSS VGISGSLPMM
   841  TDLTSVYTVS NMSARPTTVI PSSPTVQNTE ISISVSMTSA TTPSGGPTFT STENTPTRSL
   901  LTSFPMTHSF SSSMSESSAG TTHTESISSP RGTTSTLHTT VESTPSPTTT TSFTTSTMME
   961  PPSSTVSTTG RGQTTFPSST ATFPETTTLT PTTDISTVSL TTAMTSPPPV SSSITPTNTM
  1021  TSMRTTTYWP TATNTLSPLT SSILSSTPVP STEMITSHTT NTTPLSTLVT TLLTTITRST
  1081  PTSETTYPTS PTSIVSDSTT EITYSTSITG TLSTATTLPP TSSSLPTTET ATMTPTTTLI
  1141  TTTPNTTSLS TPSFTSSTIY STVSTSTTAI SSASPTSGTM VTSTTMTPSS LSTDTPSTTP
  1201  TTITYPSVGS TGFLTTATDL TSTFTVSSSS AMSTSVIPSS PSIQNTETSS LVSMTSATTP
  1261  SLRPTITSTD STLTSSLLTT FPSTYSFSSS MSASSAGTTH TETISSLPAS TNTIHTTAES
  1321  ALAPTTTTSF TTSPTMEPPS TTVATTGTGQ TTFPSSTATF LETTTLTPTT DFSTESLTTA
  1381  MTSTPPITSS ITPTDTMTSM RTTTSWPTAT NTLSPLTSSI LSSTPVPSTE VTTSHTTNTN
  1441  PVSTLVTTLP ITITRSTLTS ETAYPSSPTS TVTESTTEIT YPTTMTETSS TATSLPPTSS
  1501  LVSTAETAKT PTTNLVTTTT KTTSHSTTSF TSSTIYSTAS TPTTAITSVP TTLGTMVTST
  1561  SMIPSTVSTG IPTSQPTTIT PSSVGISGSL PMMTDLTSVY TVSSMSARPT SVIPSSPTVQ
  1621  NTETSIFVSM MSATTPSGGP TFTSTENTPT RSLLTSFPVT HSFSSSMSAS SVGTTHTQSI
  1681  SSPPAITSTL HTTAESTPSP TTTMSFTTFT KMETPSSTVA TTGTGQTTFT SSTATSPKTT
  1741  TLTPTSDIST GSFKTAVSST PPITSSITST YTVTSMTTTT PLGPTATNTL PSFTSSVSSS
  1801  TPVPSTEAIT SGTTNTTPLS TLVTTFSNSD TSSTPTSETT YPTSLTSALT DSTTRTTYST
  1861  NMTGTLSTVT SLRPTSSSLL TTVTATVPTT NLVTTTTKIT SHSTPSFTSS IATTETPSHS
  1921  TPRFTSSITT TETPSHSTPR FTSSITNTKT TSHSSPSFTS SITTTETTSH NTPSLTSSIT
  1981  TTKTTSHSTP SYTSLITTTT TTSHSTPSFT SSITTTETTS HNTPSLTSSI TTTETTSHST
  2041  PSFTSSITTE TTSHSTPSFT SLITITEITS HSTLSYTTSI TTTETPSHST LSFTSSITTT
  2101  ETTSHSTPSF TSSITTSEMP SHSTPSFTSS ITTTENATHS TPNFTSSITT TETTSHSTPS
  2161  FTSLITTTET TSHRWGTTET TSYSTPSFTS SNTITETTSH STPSYITSIT TTETPSSSTP
  2221  SFSSSITTTE TTSHSTPGFT SSITTTETTS HSTPSFTSSI TTTETTSHDT PSFTSSITTS
  2281  ETPSHSTPSS TSLITTTKTT SHSTPSFTSS ITTTETTSHS AHSFTSSITT TETTSHNTRS
  2341  FTSSITTTET NSHSTTSFTS SITTTETTSH STPSFSSSIT TTETPLHSTP GLTSWVTTTK
  2401  TTSHITPGLT SSITTTETTS HSTPGFTSSI TTTETTSEST PSLSSSTIYS TVSTSTTAIT
  2461  SHFTTSETAV TPTPVTPSSL STDIPTTSLR TLTPSSVGTS TSLTTTTDFP SIPTDISTLP
  2521  TRTHIISSSP SIQSTETSSL VGTTSPTMST VRMTLRITEN TPISSFSTSI VVIPETPTQT
  2581  PPVLTSATGT QTSPAPTTVT FGSTDSSTST LHTLTPSTAL STIVSTSQVP IPSTHSSTLQ
  2641  TTPSTPSLQT SLTSTSEFTT ESFTRGSTST NAILTSFSTI IWSSTPTIIM SSSPSSASIT
  2701  PVFSTTIHSV PSSPYIFSTE NVGSASITGF PSLSSSATTS TSSTSSSLTT ALTEITPFSY
  2761  ISLPSTTPCP GTITITIVPA SPTDPCVEMD PSTEATSPPT TPLTVFPFTT EMVTCPTSIS
  2821  IQTTLTTYMD TSSMMPESES SISPNASSST GTGTVPTNTV FTSTRLPTSE TWLSNSSVIP
  2881  LPLPGVSTIP LTMKPSSSLP TILRTSSKST HPSPPTTRTS ETPVATTQTP TTLTSRRTTR
  2941  ITSQMTTQST LTTTAGTCDN GGTWEQGQCA CLPGFSGDRC QLQTRCQNGG QWDGLKCQCP
  3001  STFYGSSCEF AVEQVDLDVV ETEVGMEVSV DQQFSPDLND NTSQAYRDFN KTFWNQMQKI
  3061  FADMQGFTFK GVEILSLRNG SIVVDYLVLL EMPFSPQLES EYEQVKTTLK EGLQNASQDV
  3121  NSCQDSQTLC FKPDSIKVNN NSKTELTPAA ICRRAAPTGY EEFYFPLVEA TRLRCVTKCT
  3181  SGVDNAIDCH QGQCVLETSG PTCRCYSTDT HWFSGPRCEV AVHWRALVGG LTAGAALLVL
  3241  LLLALGVRAV RSGWWGGQRR GRSWDQDRKW FETWDEEVVG TFSNWGFEDD GTDKDTNFYV
  3301  ALENVDTTMK VHIKRPEMTS SSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 39 nTPM
  • small intestine: 32 nTPM
  • gallbladder: 13 nTPM
  • rectum: 11 nTPM
  • thymus: 9.2 nTPM
  • colon: 8.8 nTPM

Single-cell type

  • enterocytes: 386 nCPM
  • colonocytes: 179 nCPM
  • enteric stem cells: 162 nCPM
  • goblet cells: 159 nCPM
  • paneth cells: 128 nCPM
  • enteric transient amplifying cells: 109 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 2.7 nTPM
  • hypothalamus: 2.5 nTPM
  • midbrain: 1.6 nTPM
  • medulla oblongata: 0.8 nTPM
  • thalamus: 0.8 nTPM
  • pons: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
-0.6

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MUC3A as an antibody target. Whether an autoantibody or antibody against MUC3A could matter depends on whether native MUC3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MUC3A is annotated as secreted, so native MUC3A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MUC3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MUC3A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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