Seroatlas · Human Serome Atlas

NTN5

Netrin-5

Also known as: NET5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WTR8
Gene: NTN5
Ensembl: ENSG00000142233
Chromosome: 19
Canonical length: 489 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

Predicted to be involved in neurogenesis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

489 residues, UniProt reviewed canonical sequence.

>Q8WTR8|NTN5
     1  MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS PGNHLGARET
    61  CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG PWRLLWHRPA WPGALGGPER
   121  VTFHSTPGPK ATVAASHLRV EFGGQAGLAA AGLRGRCQCH GHAARCAARA RPPRCHCRHH
   181  TTGPGCESCR PSHRDWPWRP ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE
   241  RCRHHTAGRH CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV
   301  TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN MSDTRVHMSL
   361  RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ PVRRGDQDAW VPRADLTCGC
   421  LRLQPGTDYL LLGSAVGDPD PTRLILDRHG LALPWRPRWA RPLKRLQQEE RAGGCRGVRA
   481  PTPSPRPEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 4.8 nTPM
prostate: 2.7 nTPM
fallopian tube: 2.4 nTPM
ovary: 2.2 nTPM
thyroid gland: 1.8 nTPM
cervix: 1.5 nTPM

Single-cell type

late spermatids: 19 nCPM
retinal horizontal cells: 18 nCPM
early spermatids: 14 nCPM
somatotrophs: 12 nCPM
gonadotrophs: 10 nCPM
thyrotrophs: 8.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 4.3 nTPM
basal ganglia: 4.2 nTPM
cerebral cortex: 4.2 nTPM
amygdala: 3.8 nTPM
medulla oblongata: 3.8 nTPM
midbrain: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: 1.11
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

neurogenesis

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTN5 as an antibody target. Whether an autoantibody or antibody against NTN5 could matter depends on whether native NTN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTN5 is annotated as secreted, so native NTN5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NTN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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