SCARF2

Protein identityUniProt · HPA

UniProt accession

Q96GP6

Gene

SCARF2

Ensembl

ENSG00000244486

Chromosome

22

Canonical length

871 aa

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

871 residues, UniProt reviewed canonical sequence.

>Q96GP6|SCARF2
     1  MEGAGPRGAG PARRRGAGGP PSPLLPSLLL LLLLWMLPDT VAPQELNPRG RNVCRAPGSQ
    61  VPTCCAGWRQ QGDECGIAVC EGNSTCSENE VCVRPGECRC RHGYFGANCD TKCPRQFWGP
   121  DCKELCSCHP HGQCEDVTGQ CTCHARRWGA RCEHACQCQH GTCHPRSGAC RCEPGWWGAQ
   181  CASACYCSAT SRCDPQTGAC LCHAGWWGRS CNNQCACNSS PCEQQSGRCQ CRERTFGARC
   241  DRYCQCFRGR CHPVDGTCAC EPGYRGKYCR EPCPAGFYGL GCRRRCGQCK GQQPCTVAEG
   301  RCLTCEPGWN GTKCDQPCAT GFYGEGCSHR CPPCRDGHAC NHVTGKCTRC NAGWIGDRCE
   361  TKCSNGTYGE DCAFVCADCG SGHCDFQSGR CLCSPGVHGP HCNVTCPPGL HGADCAQACS
   421  CHEDTCDPVT GACHLETNQR KGVMGAGALL VLLVCLLLSL LGCCCACRGK DPTRRPRPRR
   481  ELSLGRKKAP HRLCGRFSRI SMKLPRIPLR RQKLPKVVVA HHDLDNTLNC SFLEPPSGLE
   541  QPSPSWSSRA SFSSFDTTDE GPVYCVPHEE APAESRDPEV PTVPAEAPAP SPVPLTTPAS
   601  AEEAIPLPAS SDSERSASSV EGPGGALYAR VARREARPAR ARGEIGGLSL SPSPERRKPP
   661  PPDPATKPKV SWIHGKHSAA AAGRAPSPPP PGSEAAPSPS KRKRTPSDKS AHTVEHGSPR
   721  TRDPTPRPPG LPEEATALAA PSPPRARARG RGPGLLEPTD AGGPPRSAPE AASMLAAELR
   781  GKTRSLGRAE VALGAQGPRE KPAPPQKAKR SVPPASPARA PPATETPGPE KAATDLPAPE
   841  TPRKKTPIQK PPRKKSREAA GELGRAGAPT L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCARF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

48 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCARF2.

Disease | AllUniProt

Conditions SCARF2 is implicated in, by any mechanism.

• Van den Ende-Gupta syndrome (VDEGS) MIM:600920

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 287 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Van den Ende-Gupta syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.19

gnomAD pLI

1

gnomAD missense Z

3.02

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

Molecular functions

• scavenger receptor activity

Cellular components

• focal adhesion
• membrane

Protein domainsUniProt · Pfam · InterPro

• EGF-like domain
• Laminin-type EGF domain
• Growth factor receptor cysteine-rich domain superfamily
• MEGF10/SREC1/2-like

KeywordsUniProt

• Cell adhesion
• Disulfide bond
• EGF-like domain
• Glycoprotein
• Membrane
• Phosphoprotein
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of SCARF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SCARF1