Seroatlas · Human Serome Atlas

PEAR1

Platelet endothelial aggregation receptor 1

Also known as: FLJ00193, JEDI, MEGF12, PEAR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VY43
Gene
PEAR1
Ensembl
ENSG00000187800
Chromosome
1
Canonical length
1037 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cell Junctions,Centriolar satellite

OverviewNCBI Gene

PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1037 residues, UniProt reviewed canonical sequence.

>Q5VY43|PEAR1
     1  MSPPLCPLLL LAVGLRLAGT LNPSDPNTCS FWESFTTTTK ESHSRPFSLL PSEPCERPWE
    61  GPHTCPQPTV VYRTVYRQVV KTDHRQRLQC CHGFYESRGF CVPLCAQECV HGRCVAPNQC
   121  QCVPGWRGDD CSSECAPGMW GPQCDKPCSC GNNSSCDPKS GVCSCPSGLQ PPNCLQPCTP
   181  GYYGPACQFR CQCHGAPCDP QTGACFCPAE RTGPSCDVSC SQGTSGFFCP STHSCQNGGV
   241  FQTPQGSCSC PPGWMGTICS LPCPEGFHGP NCSQECRCHN GGLCDRFTGQ CRCAPGYTGD
   301  RCREECPVGR FGQDCAETCD CAPDARCFPA NGACLCEHGF TGDRCTDRLC PDGFYGLSCQ
   361  APCTCDREHS LSCHPMNGEC SCLPGWAGLH CNESCPQDTH GPGCQEHCLC LHGGVCQATS
   421  GLCQCAPGYT GPHCASLCPP DTYGVNCSAR CSCENAIACS PIDGECVCKE GWQRGNCSVP
   481  CPPGTWGFSC NASCQCAHEA VCSPQTGACT CTPGWHGAHC QLPCPKGQFG EGCASRCDCD
   541  HSDGCDPVHG RCQCQAGWMG ARCHLSCPEG LWGVNCSNTC TCKNGGTCLP ENGNCVCAPG
   601  FRGPSCQRSC QPGRYGKRCV PCKCANHSFC HPSNGTCYCL AGWTGPDCSQ PCPPGHWGEN
   661  CAQTCQCHHG GTCHPQDGSC ICPLGWTGHH CLEGCPLGTF GANCSQPCQC GPGEKCHPET
   721  GACVCPPGHS GAPCRIGIQE PFTVMPTTPV AYNSLGAVIG IAVLGSLVVA LVALFIGYRH
   781  WQKGKEHHHL AVAYSSGRLD GSEYVMPDVP PSYSHYYSNP SYHTLSQCSP NPPPPNKVPG
   841  PLFASLQNPE RPGGAQGHDN HTTLPADWKH RREPPPGPLD RGSSRLDRSY SYSYSNGPGP
   901  FYNKGLISEE ELGASVASLS SENPYATIRD LPSLPGGPRE SSYMEMKGPP SGSPPRQPPQ
   961  FWDSQRRRQP QPQRDSGTYE QPSPLIHDRD SVGSQPPLPP GLPPGHYDSP KNSHIPGHYD
  1021  LPPVRHPPSP PLRRQDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 17 nTPM
  • adipose tissue: 16 nTPM
  • breast: 11 nTPM
  • placenta: 11 nTPM
  • cervix: 10 nTPM
  • lung: 9.9 nTPM

Single-cell type

  • platelets: 316 nCPM
  • pericytes: 68 nCPM
  • lymphatic endothelial cells: 61 nCPM
  • leydig cells: 59 nCPM
  • peritubular myoid cells: 45 nCPM
  • vascular smooth muscle cells: 43 nCPM

Immune cell

  • total PBMC: 0.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 8.3 nTPM
  • basal ganglia: 7.7 nTPM
  • thalamus: 7.7 nTPM
  • amygdala: 6.6 nTPM
  • midbrain: 6.3 nTPM
  • pons: 6.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.71
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PEAR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEAR1 as an antibody target. Whether an autoantibody or antibody against PEAR1 could matter depends on whether native PEAR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEAR1 is annotated at the cell surface, where native PEAR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PEAR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PEAR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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