Seroatlas · Human Serome Atlas

MEGF9

Multiple epidermal growth factor-like domains protein 9

Also known as: EGFL5, MEGF9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1U4
Gene: MEGF9
Ensembl: ENSG00000106780
Chromosome: 9
Canonical length: 602 aa
Protein class: Plasma proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be located in basement membrane and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

602 residues, UniProt reviewed canonical sequence.

>Q9H1U4|MEGF9
     1  MNGGAERAMR SLPSLGGLAL LCCAAAAAAA AVASAASAGN VTGGGGAAGQ VDASPGPGLR
    61  GEPSHPFPRA TAPTAQAPRT GPPRATVHRP LAATSPAQSP ETTPLWATAG PSSTTFQAPL
   121  GPSPTTPPAA ERTSTTSQAP TRPAPTTLST TTGPAPTTPV ATTVPAPTTP RTPTPDLPSS
   181  SNSSVLPTPP ATEAPSSPPP EYVCNCSVVG SLNVNRCNQT TGQCECRPGY QGLHCETCKE
   241  GFYLNYTSGL CQPCDCSPHG ALSIPCNSSG KCQCKVGVIG SICDRCQDGY YGFSKNGCLP
   301  CQCNNRSASC DALTGACLNC QENSKGNHCE ECKEGFYQSP DATKECLRCP CSAVTSTGSC
   361  SIKSSELEPE CDQCKDGYIG PNCNKCENGY YNFDSICRKC QCHGHVDPVK TPKICKPESG
   421  ECINCLHNTT GFWCENCLEG YVHDLEGNCI KKEVILPTPE GSTILVSNAS LTTSVPTPVI
   481  NSTFTPTTLQ TIFSVSTSEN STSALADVSW TQFNIIILTV IIIVVVLLMG FVGAVYMYRE
   541  YQNRKLNAPF WTIELKEDNI SFSSYHDSIP NADVSGLLED DGNEVAPNGQ LTLTTPIHNY
   601  KA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEGF9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

retina: 63 nTPM
liver: 36 nTPM
thyroid gland: 27 nTPM
cerebral cortex: 26 nTPM
midbrain: 21 nTPM
skin: 20 nTPM

Single-cell type

neutrophils: 2,750 nCPM
neutrophil progenitors: 1,339 nCPM
cone photoreceptor cells: 857 nCPM
alveolar cells type 1: 743 nCPM
bergmann glia: 547 nCPM
retinal pigment epithelial cells: 512 nCPM

Immune cell

neutrophil: 25 nTPM
classical monocyte: 7.4 nTPM
eosinophil: 5.1 nTPM
non-classical monocyte: 4.5 nTPM
myeloid DC: 3 nTPM
intermediate monocyte: 2.5 nTPM

Brain region

medulla oblongata: 91 nTPM
white matter: 88 nTPM
thalamus: 86 nTPM
hypothalamus: 86 nTPM
midbrain: 86 nTPM
cerebellum: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.99
gnomAD missense Z: 1.43
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEGF9 as an antibody target. Whether an autoantibody or antibody against MEGF9 could matter depends on whether native MEGF9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEGF9 is annotated as secreted, so native MEGF9 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MEGF9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...