Seroatlas · Human Serome Atlas

SCARF1

Scavenger receptor class F member 1

Also known as: KIAA0149, SREC, SREC_HUMAN, SREC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14162
Gene: SCARF1
Ensembl: ENSG00000074660
Chromosome: 17
Canonical length: 830 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Canonical amino-acid sequenceUniProt

830 residues, UniProt reviewed canonical sequence.

>Q14162|SCARF1
     1  MGLGLLLPLL LLWTRGTQGS ELDPKGQHVC VASSPSAELQ CCAGWRQKDQ ECTIPICEGP
    61  DACQKDEVCV KPGLCRCKPG FFGAHCSSRC PGQYWGPDCR ESCPCHPHGQ CEPATGACQC
   121  QADRWGARCE FPCACGPHGR CDPATGVCHC EPGWWSSTCR RPCQCNTAAA RCEQATGACV
   181  CKPGWWGRRC SFRCNCHGSP CEQDSGRCAC RPGWWGPECQ QQCECVRGRC SAASGECTCP
   241  PGFRGARCEL PCPAGSHGVQ CAHSCGRCKH NEPCSPDTGS CESCEPGWNG TQCQQPCLPG
   301  TFGESCEQQC PHCRHGEACE PDTGHCQRCD PGWLGPRCED PCPTGTFGED CGSTCPTCVQ
   361  GSCDTVTGDC VCSAGYWGPS CNASCPAGFH GNNCSVPCEC PEGLCHPVSG SCQPGSGSRD
   421  TALIAGSLVP LLLLFLGLAC CACCCWAPRS DLKDRPARDG ATVSRMKLQV WGTLTSLGST
   481  LPCRSLSSHK LPWVTVSHHD PEVPFNHSFI EPPSAGWATD DSFSSDPESG EADEVPAYCV
   541  PPQEGMVPVA QAGSSEASLA AGAFPPPEDA STPFAIPRTS SLARAKRPSV SFAEGTKFAP
   601  QSRRSSGELS SPLRKPKRLS RGAQSGPEGR EAEESTGPEE AEAPESFPAA ASPGDSATGH
   661  RRPPLGGRTV AEHVEAIEGS VQESSGPVTT IYMLAGKPRG SEGPVRSVFR HFGSFQKGQA
   721  EAKVKRAIPK PPRQALNRKK GSPGLASGSV GQSPNSAPKA GLPGATGPMA VRPEEAVRGL
   781  GAGTESSRRA QEPVSGCGSP EQDPQKQAEE ERQEEPEYEN VVPISRPPEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCARF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

spleen: 26 nTPM
thyroid gland: 19 nTPM
lung: 16 nTPM
adipose tissue: 15 nTPM
breast: 13 nTPM
heart muscle: 12 nTPM

Single-cell type

choroid plexus epithelial cells: 26 nCPM
renal collecting duct intercalated cells: 20 nCPM
microglia: 20 nCPM
renal connecting tubule cells: 14 nCPM
distal convoluted tubule cells: 10 nCPM
loop of henle epithelial cells: 9.8 nCPM

Immune cell

neutrophil: 3.1 nTPM
classical monocyte: 0.9 nTPM
myeloid DC: 0.5 nTPM
intermediate monocyte: 0.2 nTPM
total PBMC: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

medulla oblongata: 3 nTPM
white matter: 2.9 nTPM
pons: 1.7 nTPM
cerebral cortex: 1.6 nTPM
basal ganglia: 1 nTPM
hypothalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: 1.14
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCARF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCARF1 as an antibody target. Whether an autoantibody or antibody against SCARF1 could matter depends on whether native SCARF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCARF1 is annotated at the cell surface, where native SCARF1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCARF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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