Seroatlas · Human Serome Atlas

NTNG1

Netrin-G1

Also known as: KIAA0976, Lmnt1, NTNG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2I2
Gene
NTNG1
Ensembl
ENSG00000162631
Chromosome
1
Canonical length
539 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

539 residues, UniProt reviewed canonical sequence.

>Q9Y2I2|NTNG1
     1  MYLSRFLSIH ALWVTVSSVM QPYPLVWGHY DLCKTQIYTE EGKVWDYMAC QPESTDMTKY
    61  LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA HPPELMFDFE GRHPSTFWQS
   121  ATWKEYPKPL QVNITLSWSK TIELTDNIVI TFESGRPDQM ILEKSLDYGR TWQPYQYYAT
   181  DCLDAFHMDP KSVKDLSQHT VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM
   241  ASLYGQLDTT KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN
   301  LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT ANTCIPSISS
   361  IGNCECFGHS NRCSYIDLLN TVICVSCKHN TRGQHCELCR LGYFRNASAQ LDDENVCIEC
   421  YCNPLGSIHD RCNGSGFCEC KTGTTGPKCD ECLPGNSWHY GCQPNVCDNE LLHCQNGGTC
   481  HNNVRCLCPA AYTGILCEKL RCEEAGSCGS DSGQGAPPHG SPALLLLTTL LGTASPLVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTNG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
9.5 nTPM

Expression across tissuesHPA

Tissue

  • retina: 9.5 nTPM
  • hypothalamus: 9.2 nTPM
  • kidney: 8.3 nTPM
  • cerebral cortex: 8 nTPM
  • seminal vesicle: 4.5 nTPM
  • adrenal gland: 4.2 nTPM

Single-cell type

  • podocytes: 3,415 nCPM
  • pituitary stem cells: 826 nCPM
  • oligodendrocyte progenitor cells: 654 nCPM
  • adrenal medulla cells: 500 nCPM
  • mesothelial cells: 412 nCPM
  • bergmann glia: 392 nCPM

Immune cell

  • memory B-cell: 1.1 nTPM
  • basophil: 0.2 nTPM
  • naive B-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM

Brain region

  • thalamus: 165 nTPM
  • midbrain: 66 nTPM
  • amygdala: 43 nTPM
  • hypothalamus: 39 nTPM
  • cerebral cortex: 23 nTPM
  • cerebellum: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.92
gnomAD missense Z
2.45
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NTNG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTNG1 as an antibody target. Whether an autoantibody or antibody against NTNG1 could matter depends on whether native NTNG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTNG1 is annotated at the cell surface, where native NTNG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NTNG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NTNG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...