Seroatlas · Human Serome Atlas

NTNG2

Netrin-G2

Also known as: KIAA1857, Lmnt2, NTNG1, NTNG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CW9
Gene
NTNG2
Ensembl
ENSG00000196358
Chromosome
9
Canonical length
530 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Predicted to be involved in axonogenesis; regulation of cell projection organization; and regulation of neuron migration. Predicted to be located in plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q96CW9|NTNG2
     1  MLHLLALFLH CLPLASGDYD ICKSWVTTDE GPTWEFYACQ PKVMRLKDYV KVKVEPSGIT
    61  CGDPPERFCS HENPYLCSNE CDASNPDLAH PPRLMFDKEE EGLATYWQSI TWSRYPSPLE
   121  ANITLSWNKT VELTDDVVMT FEYGRPTVMV LEKSLDNGRT WQPYQFYAED CMEAFGMSAR
   181  RARDMSSSSA HRVLCTEEYS RWAGSKKEKH VRFEVRDRFA IFAGPDLRNM DNLYTRLESA
   241  KGLKEFFTLT DLRMRLLRPA LGGTYVQREN LYKYFYAISN IEVIGRCKCN LHANLCSMRE
   301  GSLQCECEHN TTGPDCGKCK KNFRTRSWRA GSYLPLPHGS PNACATAGSF GNCECYGHSN
   361  RCSYIDFLNV VTCVSCKHNT RGQHCQHCRL GYYRNGSAEL DDENVCIECN CNQIGSVHDR
   421  CNETGFCECR EGAAGPKCDD CLPTHYWRQG CYPNVCDDDQ LLCQNGGTCL QNQRCACPRG
   481  YTGVRCEQPR CDPADDDGGL DCDRAPGAAP RPATLLGCLL LLGLAARLGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTNG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 24 nTPM
  • hippocampal formation: 20 nTPM
  • amygdala: 19 nTPM
  • retina: 19 nTPM
  • cerebral cortex: 17 nTPM
  • spinal cord: 11 nTPM

Single-cell type

  • cone photoreceptor cells: 172 nCPM
  • neutrophil progenitors: 168 nCPM
  • rod photoreceptor cells: 129 nCPM
  • bergmann glia: 113 nCPM
  • neutrophils: 110 nCPM
  • retinal bipolar cells: 96 nCPM

Immune cell

  • neutrophil: 1.1 nTPM
  • basophil: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 149 nTPM
  • amygdala: 42 nTPM
  • hippocampal formation: 42 nTPM
  • pons: 34 nTPM
  • cerebellum: 30 nTPM
  • thalamus: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NTNG2.

Disease | AllUniProt

Conditions NTNG2 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia (NEDBASH) MIM:618718

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 96 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
2.93
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NTNG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTNG2 as an antibody target. Whether an autoantibody or antibody against NTNG2 could matter depends on whether native NTNG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTNG2 is annotated at the cell surface, where native NTNG2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NTNG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NTNG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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