TNFR/NGFR cysteine-rich region
IPR001368
Definition
A number of proteins, some of which are known to be receptors for growth factors, have been found to contain a cysteine-rich domain of about 110 to 160 amino acids in their N-terminal part, that can be subdivided into four (or in some cases, three) modules of about 40 residues containing 6 conserved cysteines. Some of the proteins containing this domain are listed below [[cite:PMID:2174582], [cite:PMID:15335933], [cite:PMID:15335677]]: Tumor Necrosis Factor type I and type II receptors (TNFR). Both receptors bind TNF-alpha and TNF-beta, but are only similar in the cysteine-rich region. TNFR contains four cysteine-rich domain modules (CRDs), termed CRD1 through CRD4. CRD2 and CRD3 are known as TNF-binding domains PMID:8387891. Shope fibroma virus soluble TNF receptor (protein T2) Lymphotoxin alpha/beta receptor Low-affinity nerve growth factor receptor (LA-NGFR) (p75) CD40 (Bp50), the receptor for the CD40L (or TRAP) cytokine CD27, the receptor for the CD27L cytokine CD30, the receptor for the CD30L cytokine T-cell protein 4-1BB, the receptor for the 4-1BBL putative cytokine FAS antigen (or APO-1), the receptor for FASL, a protein involved in apoptosis (programmed cell death) T-cell antigen OX40, the receptor for the OX40L cytokine Wsl-1, a receptor (for a yet undefined ligand) that mediates apoptosis Vaccinia virus protein A53 (SalF19R) It has been shown PMID:8387891 that the six cysteines all involved in intrachain disulphide bonds. A schematic representation of the structure of the 40 residue module of these receptors is shown below: +-------------+ +--------------+ | | | | xCxxxxxxxxxxxxxCxCxxCxxxxxxxxxCxxxxCxx | | +------------+ 'C': conserved cysteine involved in a disulphide bond.
25 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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