TNFRSF25

Protein identityUniProt · HPA

UniProt accession

Q93038

Gene

TNFRSF25

Ensembl

ENSG00000215788

Chromosome

1

Canonical length

417 aa

Protein class

Predicted membrane proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Plasma membrane,Actin filaments,Focal adhesion sites

Secretome location

Secreted - unknown location

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q93038|TNFRSF25
     1  MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP
    61  CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG
   121  WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP
   181  TSTLGSCPER CAAVCGWRQM FWVQVLLAGL VVPLLLGATL TYTYRHCWPH KPLVTADEAG
   241  MEALTPPPAT HLSPLDSAHT LLAPPDSSEK ICTVQLVGNS WTPGYPETQE ALCPQVTWSW
   301  DQLPSRALGP AAAPTLSPES PAGSPAMMLQ PGPQLYDVMD AVPARRWKEF VRTLGLREAE
   361  IEAVEVEIGR FRDQQYEMLK RWRQQQPAGL GAVYAALERM GLDGCVEDLR SRLQRGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

42 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.6

gnomAD pLI

0.01

gnomAD missense Z

1.57

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• apoptotic signaling pathway
• cell surface receptor signaling pathway
• regulation of apoptotic process
• signal transduction

Molecular functions

• signaling receptor activity
• tumor necrosis factor receptor activity

Cellular components

• cytosol
• extracellular region
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Death domain
• TNFR/NGFR cysteine-rich region
• Death-like domain superfamily
• TNFR/NGFR cysteine-rich region
• Death domain
• Tumour necrosis factor receptor 25
• Tumor necrosis factor receptor 25, N-terminal

KeywordsUniProt

• Apoptosis
• Cell membrane
• Disulfide bond
• Glycoprotein
• Membrane
• Receptor
• Repeat
• Secreted
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TNFRSF25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BAG4