Seroatlas · Human Serome Atlas

TNFRSF6B

Tumor necrosis factor receptor superfamily member 6B

Also known as: DcR3, M68, TNF6B_HUMAN, TR6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95407
Gene
TNFRSF6B
Ensembl
ENSG00000243509
Chromosome
20
Canonical length
300 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>O95407|TNFRSF6B
     1  MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR
    61  PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF
   121  AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA
   181  LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE
   241  GWGPTPRAGR AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • lung: 53 nTPM
  • spleen: 40 nTPM
  • spinal cord: 33 nTPM
  • adipose tissue: 30 nTPM
  • basal ganglia: 28 nTPM
  • hippocampal formation: 28 nTPM

Single-cell type

  • brain inhibitory neurons: 11 nCPM
  • astrocytes: 8.5 nCPM
  • brain excitatory neurons: 8.2 nCPM
  • other brain neurons: 7.9 nCPM
  • oligodendrocytes: 4.9 nCPM
  • bergmann glia: 4.8 nCPM

Immune cell

  • plasmacytoid DC: 22 nTPM
  • non-classical monocyte: 1.3 nTPM
  • naive CD4 T-cell: 0.4 nTPM
  • intermediate monocyte: 0.3 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • T-reg: 0.1 nTPM

Brain region

  • thalamus: 21 nTPM
  • medulla oblongata: 19 nTPM
  • pons: 17 nTPM
  • hypothalamus: 17 nTPM
  • spinal cord: 15 nTPM
  • amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0
gnomAD missense Z
-1.3
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNFRSF6B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFRSF6B as an antibody target. Whether an autoantibody or antibody against TNFRSF6B could matter depends on whether native TNFRSF6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFRSF6B is annotated as secreted, so native TNFRSF6B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TNFRSF6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNFRSF6B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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