Seroatlas · Human Serome Atlas

TNFRSF10D

Tumor necrosis factor receptor superfamily member 10D

Also known as: CD264, DcR2, TR10D_HUMAN, TRAILR4, TRUNDD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBN6
Gene: TNFRSF10D
Ensembl: ENSG00000173530
Chromosome: 8
Canonical length: 386 aa
Protein class: Cancer-related genes, CD markers, Predicted membrane proteins
Subcellular location: Plasma membrane,Actin filaments

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>Q9UBN6|TNFRSF10D
     1  MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP VRVDSATIPR
    61  QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT EGVDYTIASN NLPSCLLCTV
   121  CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC
   181  KNESAASSTG KTPAAEETVT TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL
   241  KGICSGGGGG PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL
   301  AELTGVTVEL PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS ATLEEGHAKE
   361  TIQDQLVGSE KLFYEEDEAG SATSCL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF10D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

liver: 17 nTPM
adipose tissue: 10 nTPM
lung: 9.5 nTPM
kidney: 8.6 nTPM
bone marrow: 8.5 nTPM
gallbladder: 7.4 nTPM

Single-cell type

vascular endothelial cells: 308 nCPM
enterocytes: 209 nCPM
salivary myoepithelial cells: 153 nCPM
colonocytes: 152 nCPM
lymphatic endothelial cells: 145 nCPM
ovarian stromal cells: 115 nCPM

Immune cell

naive CD4 T-cell: 5.2 nTPM
myeloid DC: 2.9 nTPM
basophil: 2.5 nTPM
classical monocyte: 2.1 nTPM
naive CD8 T-cell: 2.1 nTPM
memory CD4 T-cell: 1.9 nTPM

Brain region

choroid plexus: 6.8 nTPM
thalamus: 6.5 nTPM
spinal cord: 4.7 nTPM
cerebral cortex: 4.6 nTPM
pons: 4.6 nTPM
medulla oblongata: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.01
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFRSF10D as an antibody target. Whether an autoantibody or antibody against TNFRSF10D could matter depends on whether native TNFRSF10D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFRSF10D is annotated at the cell surface, where native TNFRSF10D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TNFRSF10D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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