CD27
CD27 antigen
Also known as: CD27_HUMAN, S152, TNFRSF7, Tp55
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P26842
- Gene
- CD27
- Ensembl
- ENSG00000139193
- Chromosome
- 12
- Canonical length
- 260 aa
- Protein class
- Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins
- Subcellular location
- Vesicles
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
260 residues, UniProt reviewed canonical sequence.
>P26842|CD27
1 MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV KDCDQHRKAA
61 QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA NAECACRNGW QCRDKECTEC
121 DPLPNPSLTA RSSQALSPHP QPTHLPYVSE MLEARTAGHM QTLADFRQLP ARTLSTHWPP
181 QRSLCSSDFI RILVIFSGMF LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCHYSCPREE
241 EGSTIPIQED YRKPEPACSPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CD27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 138 nTPM
Expression across tissuesHPA
Tissue
- lymph node: 138 nTPM
- tonsil: 100 nTPM
- spleen: 78 nTPM
- appendix: 56 nTPM
- thymus: 42 nTPM
- small intestine: 37 nTPM
Single-cell type
- plasma cells: 472 nCPM
- t-cells: 86 nCPM
- b-cells: 75 nCPM
- epicardial cells: 64 nCPM
- cardiomyocytes: 61 nCPM
- foveolar cells: 17 nCPM
Immune cell
- T-reg: 642 nTPM
- naive CD4 T-cell: 384 nTPM
- memory B-cell: 294 nTPM
- memory CD4 T-cell: 284 nTPM
- naive CD8 T-cell: 282 nTPM
- memory CD8 T-cell: 263 nTPM
Brain region
- white matter: 3.5 nTPM
- pons: 3.2 nTPM
- basal ganglia: 2.6 nTPM
- medulla oblongata: 2.5 nTPM
- cerebral cortex: 2.4 nTPM
- thalamus: 2.4 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about CD27.
Disease | AllUniProt
Conditions CD27 is implicated in, by any mechanism.
- Lymphoproliferative syndrome 2 (LPFS2) MIM:615122
Disease | GeneticClinVar
18 pathogenic / likely-pathogenic of 249 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Lymphoproliferative syndrome 2
- Immunodeficiency
- Combined immunodeficiency
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.92
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.13
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adaptive immune memory response involving T cells and B cells
- CD27 signaling pathway
- cell surface receptor signaling pathway
- extrinsic apoptotic signaling pathway
- immunoglobulin mediated immune response
- negative regulation of apoptotic process
- negative regulation of T cell apoptotic process
- positive regulation of B cell differentiation
- positive regulation of JNK cascade
- positive regulation of non-canonical NF-kappaB signal transduction
- positive regulation of T cell differentiation
- response to ethanol
- T cell activation
Molecular functions
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- transmembrane signaling receptor activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- TNFR/NGFR cysteine-rich region
- TNFR/NGFR cysteine-rich region
- Tumour necrosis factor receptor 7
- Tumour necrosis factor receptor 7, N-terminal
- CD27 antigen receptor
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CD27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CD27 as an antibody target. Whether an autoantibody or antibody against CD27 could matter depends on whether native CD27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CD27 is annotated at the cell surface, where native CD27 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CD27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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