Seroatlas · Human Serome Atlas

LTBR

Tumor necrosis factor receptor superfamily member 3

Also known as: D12S370, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFRSF3, TNR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P36941
Gene
LTBR
Ensembl
ENSG00000111321
Chromosome
12
Canonical length
435 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>P36941|LTBR
     1  MLLPWATSAP GLAWGPLVLG LFGLLAASQP QAVPPYASEN QTCRDQEKEY YEPQHRICCS
    61  RCPPGTYVSA KCSRIRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EEIAPCTSKR
   121  KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS
   181  PSARCQPHTR CENQGLVEAA PGTAQSDTTC KNPLEPLPPE MSGTMLMLAV LLPLAFFLLL
   241  ATVFSCIWKS HPSLCRKLGS LLKRRPQGEG PNPVAGSWEP PKAHPYFPDL VQPLLPISGD
   301  VSPVSTGLPA APVLEAGVPQ QQSPLDLTRE PQLEPGEQSQ VAHGTNGIHV TGGSMTITGN
   361  IYIYNGPVLG GPPGPGDLPA TPEPPYPIPE EGDPGPPGLS TPHQEDGKAW HLAETEHCGA
   421  TPSNRGPRNQ FITHD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTBR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
137 nTPM

Expression across tissuesHPA

Tissue

  • liver: 137 nTPM
  • esophagus: 84 nTPM
  • pancreas: 81 nTPM
  • skin: 77 nTPM
  • colon: 73 nTPM
  • stomach: 69 nTPM

Single-cell type

  • esophageal apical cells: 193 nCPM
  • alveolar cells type 1: 151 nCPM
  • enterocytes: 113 nCPM
  • esophageal suprabasal cells: 104 nCPM
  • esophageal basal cells: 91 nCPM
  • prostatic hillock cells: 82 nCPM

Immune cell

  • classical monocyte: 71 nTPM
  • intermediate monocyte: 66 nTPM
  • non-classical monocyte: 50 nTPM
  • myeloid DC: 50 nTPM
  • neutrophil: 45 nTPM
  • total PBMC: 27 nTPM

Brain region

  • medulla oblongata: 21 nTPM
  • pons: 19 nTPM
  • thalamus: 18 nTPM
  • choroid plexus: 17 nTPM
  • spinal cord: 16 nTPM
  • midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.31
gnomAD missense Z
2.03
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LTBR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LTBR as an antibody target. Whether an autoantibody or antibody against LTBR could matter depends on whether native LTBR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LTBR is annotated at the cell surface, where native LTBR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LTBR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LTBR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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