Seroatlas · Human Serome Atlas

MT1HL1

Metallothionein 1H-like protein 1

Also known as: M1BL1_HUMAN, MT1P2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DM35
Gene
MT1HL1
Ensembl
ENSG00000244020
Chromosome
1
Canonical length
61 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene is a retrotransposed gene, compared to MT1H (GeneID:4496). This retrogene is transcribed. It retains a full-length CDS, and is assumed to be translated. Compared to the MT1H product, this protein product differs at three internal amino acids, two of which are at metal-binding sites. [provided by RefSeq, Mar 2013]

Canonical amino-acid sequenceUniProt

61 residues, UniProt reviewed canonical sequence.

>P0DM35|MT1HL1
     1  MDPNCSCAAG GSYACAGSCK CKKCKCTSCK KSCCSCCPLG CAKCAQGCIR KGASEKCSCC
    61  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT1HL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
5.5 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 5.5 nTPM
  • liver: 1.4 nTPM
  • kidney: 1 nTPM
  • skeletal muscle: 0.3 nTPM
  • pancreas: 0.2 nTPM
  • thyroid gland: 0.2 nTPM

Single-cell type

  • endometrial luminal cells: 3.5 nCPM
  • cardiomyocytes: 2.7 nCPM
  • parietal cells: 1.8 nCPM
  • proximal tubule cells: 1.7 nCPM
  • hepatocytes: 1.4 nCPM
  • extravillous trophoblasts: 0.8 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • basal ganglia: 1.1 nTPM
  • cerebral cortex: 0.8 nTPM
  • amygdala: 0.5 nTPM
  • hypothalamus: 0.5 nTPM
  • medulla oblongata: 0.5 nTPM
  • pons: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.27
DepMap mean gene effect
-0.21
DepMap dependency class
selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT1HL1 as an antibody target. Whether an autoantibody or antibody against MT1HL1 could matter depends on whether native MT1HL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT1HL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MT1HL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MT1HL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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