TNFRSF19

Protein identityUniProt · HPA

UniProt accession

Q9NS68

Gene

TNFRSF19

Ensembl

ENSG00000127863

Chromosome

13

Canonical length

423 aa

Protein class

Plasma proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9NS68|TNFRSF19
     1  MALKVLLEQE KTFFTLLVLL GYLSCKVTCE SGDCRQQEFR DRSGNCVPCN QCGPGMELSK
    61  ECGFGYGEDA QCVTCRLHRF KEDWGFQKCK PCLDCAVVNR FQKANCSATS DAICGDCLPG
   121  FYRKTKLVGF QDMECVPCGD PPPPYEPHCA SKVNLVKIAS TASSPRDTAL AAVICSALAT
   181  VLLALLILCV IYCKRQFMEK KPSWSLRSQD IQYNGSELSC FDRPQLHEYA HRACCQCRRD
   241  SVQTCGPVRL LPSMCCEEAC SPNPATLGCG VHSAASLQAR NAGPAGEMVP TFFGSLTQSI
   301  CGEFSDAWPL MQNPMGGDNI SFCDSYPELT GEDIHSLNPE LESSTSLDSN SSQDLVGGAV
   361  PVQSHSENFT AATDLSRYNN TLVESASTQD ALTMRSQLDQ ESGAVIHPAT QTSLQVRQRL
   421  GSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

102 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.72

gnomAD pLI

0.03

gnomAD missense Z

0.23

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• hair follicle development
• JNK cascade
• positive regulation of canonical NF-kappaB signal transduction
• positive regulation of JNK cascade

Molecular functions

• signaling receptor activity
• tumor necrosis factor receptor activity

Cellular components

• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• TNFR/NGFR cysteine-rich region
• Tumor necrosis factor receptor superfamily member 19/27/EDAR
• Tumour necrosis factor receptor 19
• Tumor necrosis factor receptor 19, N-terminal

KeywordsUniProt

• Apoptosis
• Disulfide bond
• Glycoprotein
• Membrane
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TNFRSF19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LINGO1